Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 839642..840291 Replicon chromosome
Accession NZ_CP042856
Organism Salinibacterium sp. dk2585

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FVA74_RS03965 Protein ID WP_147720529.1
Coordinates 839642..840043 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FVA74_RS03970 Protein ID WP_147720531.1
Coordinates 840040..840291 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FVA74_RS03945 835757..836251 + 495 WP_147720524.1 5-(carboxyamino)imidazole ribonucleotide mutase -
FVA74_RS03950 836276..837604 + 1329 WP_147723052.1 LCP family protein -
FVA74_RS03955 837614..838786 - 1173 WP_147720525.1 glycosyltransferase family 4 protein -
FVA74_RS03960 838783..839634 - 852 WP_147720527.1 dTDP-4-dehydrorhamnose reductase -
FVA74_RS03965 839642..840043 - 402 WP_147720529.1 PIN domain-containing protein Toxin
FVA74_RS03970 840040..840291 - 252 WP_147720531.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
FVA74_RS03975 840340..841335 - 996 WP_147720533.1 dTDP-glucose 4,6-dehydratase -
FVA74_RS03980 841553..843586 + 2034 WP_168220041.1 acyltransferase -
FVA74_RS03985 843590..844471 - 882 WP_147720535.1 glycosyltransferase family 2 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-41)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14400.44 Da        Isoelectric Point: 6.4897

>T136241 WP_147720529.1 NZ_CP042856:c840043-839642 [Salinibacterium sp. dk2585]
MTERAGLLDTSVLIAVEQHRSLDHARLPLQQHVSVISRGELYAGVHASQTPEVRAARLATLESIAGLSLLAIGRDEATEW
GRLRYALAAAKRRVNVNDLWIAAIAVANGLPVITQDDDFDIIHEHGGPAVIKV

Download         Length: 402 bp

>T136241 NZ_CP055294:744104-744589 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9390.72 Da        Isoelectric Point: 4.8380

>AT136241 WP_147720531.1 NZ_CP042856:c840291-840040 [Salinibacterium sp. dk2585]
MTEVPVRELRNHTADVIERARRGEEVTITVNGVPAAKLIAVTPPLKQYLTVEDLMAMRPKRPINEPHPHDVWDDTTDELG
PIE

Download         Length: 252 bp

>AT136241 NZ_CP042856:c840291-840040 [Salinibacterium sp. dk2585]
ATGACCGAAGTGCCCGTGCGCGAACTGCGGAACCACACCGCCGATGTCATCGAACGCGCCCGCAGAGGTGAAGAAGTCAC
GATCACCGTGAACGGCGTTCCGGCCGCCAAGCTGATTGCCGTCACACCGCCGCTCAAGCAGTACCTGACGGTGGAAGATC
TGATGGCAATGCGGCCGAAGCGTCCCATCAACGAACCGCATCCTCACGATGTATGGGACGATACGACCGACGAGCTTGGC
CCGATCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References