Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 22449..23245 Replicon chromosome
Accession NZ_CP042856
Organism Salinibacterium sp. dk2585

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag FVA74_RS00120 Protein ID WP_147719766.1
Coordinates 22449..22949 (-) Length 167 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag FVA74_RS00125 Protein ID WP_147719767.1
Coordinates 22946..23245 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FVA74_RS00095 17831..18343 + 513 WP_147719761.1 single-stranded DNA-binding protein -
FVA74_RS00100 18392..18652 + 261 WP_147719762.1 30S ribosomal protein S18 -
FVA74_RS00105 18664..19116 + 453 WP_147719763.1 50S ribosomal protein L9 -
FVA74_RS00110 19617..20996 + 1380 WP_147719764.1 replicative DNA helicase -
FVA74_RS00115 21136..22461 + 1326 WP_147719765.1 hypothetical protein -
FVA74_RS00120 22449..22949 - 501 WP_147719766.1 GNAT family N-acetyltransferase Toxin
FVA74_RS00125 22946..23245 - 300 WP_147719767.1 DUF1778 domain-containing protein Antitoxin
FVA74_RS00130 23483..24211 + 729 WP_147722982.1 SUMF1/EgtB/PvdO family nonheme iron enzyme -
FVA74_RS13495 24426..24566 + 141 WP_168220000.1 hypothetical protein -
FVA74_RS00135 24646..25248 + 603 WP_147719768.1 hypothetical protein -
FVA74_RS00140 25245..25499 + 255 WP_147719769.1 hypothetical protein -
FVA74_RS00145 25618..27003 - 1386 WP_147719770.1 adenylosuccinate lyase -
FVA74_RS00150 27000..27521 - 522 WP_147722983.1 low molecular weight phosphotyrosine protein phosphatase -
FVA74_RS00155 27681..27914 + 234 WP_147719771.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(23-138)

Antitoxin

Vibrio phage ICP1, Orf50

(15-91)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 18698.18 Da        Isoelectric Point: 8.4642

>T136240 WP_147719766.1 NZ_CP042856:c22949-22449 [Salinibacterium sp. dk2585]
VTRFSSPRKLQKSDRREGFSSGAPELDDWFVRFAWENQAANNATTYVTYHGERVAGFYSVTMAAVAQDNAPERLAARRPT
QIPCILLARLAVDTEFKGNGLGWSLLRDALRRAYQISESIGAAAVLVHCRDEGAKSFYLYHGDFLQSPVEELHLMVPMKA
LRRYAE

Download         Length: 501 bp

>T136240 NZ_CP055294:355277-355624 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11509.99 Da        Isoelectric Point: 5.2252

>AT136240 WP_147719767.1 NZ_CP042856:c23245-22946 [Salinibacterium sp. dk2585]
MSESAADTRLAKNQRINLRATDRQENLLRRAAEATDHTLTEFILGSAVEHAERVLADRRWFIATEEQFEEFSRMLDLPLP
KLTKFEKLFSRPTVFSDDV

Download         Length: 300 bp

>AT136240 NZ_CP055294:355624-355923 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References