Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 421539..422036 Replicon chromosome
Accession NZ_CP042845
Organism Escherichia coli strain JME65

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag FVE21_RS01935 Protein ID WP_001173343.1
Coordinates 421863..422036 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag FVE21_RS01930 Protein ID WP_000398619.1
Coordinates 421539..421835 (+) Length 99 a.a.

Genomic Context

FVE21_RS01920FVE21_RS01925FVE21_RS01930FVE21_RS01935FVE21_RS01910FVE21_RS01915FVE21_RS01940FVE21_RS01945
Location: 420798..421028 (231 bp)
Type: Others
Protein ID: WP_000371704.1
Location: 421040..421312 (273 bp)
Type: Others
Protein ID: WP_000405651.1
Location: 421539..421835 (297 bp)
Type: Antitoxin
Protein ID: WP_000398619.1
Location: 421863..422036 (174 bp)
Type: Toxin
Protein ID: WP_001173343.1
Location: 418270..418989 (720 bp)
Type: Others
Protein ID: WP_000611288.1
Location: 418986..420617 (1632 bp)
Type: Others
Protein ID: WP_001216477.1
Location: 422155..423672 (1518 bp)
Type: Others
Protein ID: WP_001295074.1
Location: 423909..425366 (1458 bp)
Type: Others
Protein ID: WP_000856829.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FVE21_RS01910418270..418989-720WP_000611288.1two-component system response regulator DcuR-
FVE21_RS01915418986..420617-1632WP_001216477.1sensor histidine kinase-
FVE21_RS01920420798..421028+231WP_000371704.1(4Fe-4S)-binding protein-
FVE21_RS01925421040..421312+273WP_000405651.1N-acetyltransferase-
FVE21_RS01930421539..421835+297WP_000398619.1type V toxin-antitoxin system endoribonuclease antitoxin GhoSAntitoxin
FVE21_RS01935421863..422036+174WP_001173343.1type V toxin-antitoxin system toxin GhoTToxin
FVE21_RS01940422155..423672-1518WP_001295074.1lysine--tRNA ligase-
FVE21_RS01945423909..425366-1458WP_000856829.1dipeptide/tripeptide permease DtpC-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T136154 WP_001173343.1 NZ_CP042845:421863-422036 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

>T136154 NZ_CP042845:421863-422036 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT136154 WP_000398619.1 NZ_CP042845:421539-421835 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp

>AT136154 NZ_CP042845:421539-421835 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A7U9QI41

Antitoxin

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Source
ID
Structure
PDB2LLZ
AlphaFold DBA0A7U9QBH6

References