Detailed information of TA system TA136065

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 454337..454990
• Replicon: chromosome
• Accession: NZ_CP042841
• Organism: Acinetobacter baumannii strain ATCC BAA-1790

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: BAA1790NC_RS02220
• Protein ID: WP_000607077.1
• Coordinates: 454601..454990 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: BAA1790NC_RS02215
• Protein ID: WP_001288210.1
• Coordinates: 454337..454594 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BAA1790NC_RS02195	449853..450860	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
BAA1790NC_RS02200	450879..451256	+	378	WP_001216380.1	50S ribosomal protein L17	-
BAA1790NC_RS02205	451438..452928	+	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
BAA1790NC_RS02210	452977..454149	-	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
BAA1790NC_RS02215	454337..454594	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
BAA1790NC_RS02220	454601..454990	+	390	WP_000607077.1	membrane protein	Toxin
BAA1790NC_RS02225	455760..456845	+	1086	WP_000049106.1	hypothetical protein	-
BAA1790NC_RS02230	456923..457489	+	567	WP_000651538.1	rhombosortase	-
BAA1790NC_RS02235	457677..459872	+	2196	WP_001158906.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T136065 WP_000607077.1 NZ_CP042841:454601-454990 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T136065 NZ_CP042841:454601-454990 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT136065 WP_001288210.1 NZ_CP042841:454337-454594 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT136065 NZ_CP042841:454337-454594 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7