Detailed information of TA system TA136063

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1820513..1821006
• Replicon: chromosome
• Accession: NZ_CP042839
• Organism: Enterococcus sp. DA9

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FTX43_RS09710
• Protein ID: WP_002292138.1
• Coordinates: 1820740..1821006 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FTX43_RS09705
• Protein ID: WP_002320124.1
• Coordinates: 1820513..1820743 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FTX43_RS09675	1817492..1818250	+	759	WP_002342169.1	restriction endonuclease	-
FTX43_RS09685	1818482..1818907	-	426	WP_002290432.1	hypothetical protein	-
FTX43_RS09690	1818925..1819182	-	258	WP_002313665.1	hypothetical protein	-
FTX43_RS14940	1819384..1819686	+	303	Protein_1713	hypothetical protein	-
FTX43_RS14945	1819702..1820038	+	337	Protein_1714	hypothetical protein	-
FTX43_RS09705	1820513..1820743	+	231	WP_002320124.1	hypothetical protein	Antitoxin
FTX43_RS09710	1820740..1821006	+	267	WP_002292138.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FTX43_RS09715	1821258..1821485	+	228	WP_002313668.1	hypothetical protein	-
FTX43_RS09720	1821501..1822667	+	1167	WP_002313669.1	oxygen-independent coproporphyrinogen III oxidase	-
FTX43_RS09725	1822901..1823944	+	1044	WP_002292136.1	heat-inducible transcriptional repressor HrcA	-
FTX43_RS09730	1824038..1824601	+	564	WP_002292135.1	nucleotide exchange factor GrpE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Protein of unknown function DUF6290 (1-72)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10556.21 Da
• Isoelectric Point: 10.3338

>T136063 WP_002292138.1 NZ_CP042839:1820740-1821006 [Enterococcus sp. DA9]
MTYRLEFTPEIQKQLRKMDKHQATLIVRWLYQHIDGIDDPRKFGKGLTANRSGQWRYRIGKYRVLVEIEDNQIVVIAIQV
GHRKNVYD

Nucleotide

• Length: 267 bp

>T136063 NZ_CP042839:1820740-1821006 [Enterococcus sp. DA9]
ATGACCTACCGTTTAGAATTCACGCCTGAAATTCAGAAACAACTTCGTAAAATGGACAAGCATCAAGCGACGCTGATCGT
TCGATGGCTATATCAACATATTGATGGTATTGACGATCCGAGAAAATTCGGAAAAGGATTGACCGCTAATCGTTCAGGAC
AATGGCGTTATCGAATTGGCAAATATCGTGTGTTGGTAGAGATAGAAGATAATCAAATAGTTGTTATCGCTATTCAAGTG
GGACACCGAAAAAATGTCTATGATTAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8829.97 Da
• Isoelectric Point: 4.0887

>AT136063 WP_002320124.1 NZ_CP042839:1820513-1820743 [Enterococcus sp. DA9]
MAMITVRVSDAEKEWLSYMAEFYGITLSELLKTYSMEQLEDEYDCQTAEIAHKHWVESGKTTVSMEEILREFGGLE

Nucleotide

• Length: 231 bp

>AT136063 NZ_CP042839:1820513-1820743 [Enterococcus sp. DA9]
ATGGCTATGATTACGGTTCGTGTGAGTGATGCCGAAAAAGAATGGCTTTCTTATATGGCGGAATTTTATGGGATTACTTT
ATCTGAGCTTCTAAAAACCTATTCGATGGAACAACTAGAAGATGAATACGATTGTCAAACGGCTGAAATTGCCCATAAAC
ATTGGGTAGAAAGTGGAAAAACAACAGTATCCATGGAAGAAATCCTTCGTGAATTTGGAGGGTTGGAATGA