Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 2421974..2422467 Replicon chromosome
Accession NZ_CP042834
Organism Enterococcus faecium strain FA3

Toxin (Protein)


Gene name relE Uniprot ID A0A133MTG0
Locus tag FTX41_RS13110 Protein ID WP_002329323.1
Coordinates 2421974..2422240 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A829AAJ0
Locus tag FTX41_RS13115 Protein ID WP_002329324.1
Coordinates 2422237..2422467 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FTX41_RS13090 2418380..2418943 - 564 WP_002292135.1 nucleotide exchange factor GrpE -
FTX41_RS13095 2419037..2420080 - 1044 WP_002329320.1 heat-inducible transcriptional repressor HrcA -
FTX41_RS13100 2420313..2421479 - 1167 WP_002329321.1 oxygen-independent coproporphyrinogen III oxidase -
FTX41_RS13105 2421495..2421722 - 228 WP_002329322.1 hypothetical protein -
FTX41_RS13110 2421974..2422240 - 267 WP_002329323.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FTX41_RS13115 2422237..2422467 - 231 WP_002329324.1 hypothetical protein Antitoxin
FTX41_RS13130 2422943..2423278 - 336 WP_002329326.1 hypothetical protein -
FTX41_RS13135 2423291..2423596 - 306 WP_002329327.1 hypothetical protein -
FTX41_RS13140 2423846..2424805 + 960 WP_002293280.1 IS30-like element IS6770 family transposase -
FTX41_RS13145 2425452..2426042 + 591 WP_002329329.1 glutamine amidotransferase -
FTX41_RS13150 2426252..2426695 - 444 WP_002329330.1 hypothetical protein -
FTX41_RS13155 2426696..2427463 - 768 WP_002329331.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2423846..2424805 959


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10617.27 Da        Isoelectric Point: 10.1925

>T136061 WP_002329323.1 NZ_CP042834:c2422240-2421974 [Enterococcus faecium]
MTYRLEFTPEIQKQLRKMDKHQATLIVRWLYQHIDGIDDPRKFGKGLTANRSGQWRYRIGKYRVLVEIEDDQMVVIAIQV
GHRRNIYD

Download         Length: 267 bp

>T136061 NZ_CP042834:c2422240-2421974 [Enterococcus faecium]
ATGACCTACCGTTTAGAATTCACGCCTGAAATTCAGAAACAACTTCGTAAAATGGACAAGCATCAAGCGACGCTGATTGT
TCGATGGCTGTATCAACATATTGATGGTATTGACGATCCGAGAAAATTCGGAAAAGGATTGACCGCTAATCGTTCAGGAC
AATGGCGTTATCGAATTGGCAAATATCGTGTGTTGGTAGAGATAGAAGATGATCAAATGGTTGTTATCGCTATTCAAGTG
GGACACCGAAGAAATATCTATGATTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8863.97 Da        Isoelectric Point: 4.1938

>AT136061 WP_002329324.1 NZ_CP042834:c2422467-2422237 [Enterococcus faecium]
MAMITVRVSDAEKEWLSYMAEFYGITLSELLKTYSMEQLEDEYDRQTAEIAHKHWVESGKTTVSMEEILHEFGGLE

Download         Length: 231 bp

>AT136061 NZ_CP042834:c2422467-2422237 [Enterococcus faecium]
ATGGCTATGATTACGGTTCGTGTGAGTGATGCCGAAAAAGAATGGCTTTCTTATATGGCGGAATTTTATGGGATTACTTT
ATCTGAGCTTCTAAAAACCTATTCGATGGAACAACTAGAAGATGAATACGATCGTCAAACGGCTGAAATTGCCCATAAAC
ATTGGGTAGAAAGTGGAAAAACAACAGTATCCATGGAAGAAATCCTTCATGAATTTGGAGGGCTGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A133MTG0

Antitoxin

Source ID Structure
AlphaFold DB A0A829AAJ0

References