Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 4922950..4923593 Replicon chromosome
Accession NZ_CP042828
Organism Ruania sp. HY168

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FU260_RS22720 Protein ID WP_147919120.1
Coordinates 4922950..4923339 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FU260_RS22725 Protein ID WP_147919121.1
Coordinates 4923336..4923593 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FU260_RS22705 4919197..4920372 + 1176 WP_210418354.1 ROK family protein -
FU260_RS22710 4920414..4921895 + 1482 WP_210418355.1 sulfatase-like hydrolase/transferase -
FU260_RS22715 4922040..4922900 + 861 WP_147919119.1 SDR family oxidoreductase -
FU260_RS22720 4922950..4923339 - 390 WP_147919120.1 PIN domain-containing protein Toxin
FU260_RS22725 4923336..4923593 - 258 WP_147919121.1 hypothetical protein Antitoxin
FU260_RS22730 4923679..4924302 - 624 WP_147919122.1 SagB/ThcOx family dehydrogenase -
FU260_RS22735 4924508..4925470 + 963 WP_147919123.1 ABC transporter ATP-binding protein -
FU260_RS22740 4925467..4926228 + 762 WP_147919124.1 ABC transporter permease -
FU260_RS22745 4926255..4927385 + 1131 WP_210418158.1 sensor histidine kinase -
FU260_RS22750 4927382..4927996 + 615 WP_147919125.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-118)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14168.13 Da        Isoelectric Point: 4.9318

>T136059 WP_147919120.1 NZ_CP042828:c4923339-4922950 [Ruania sp. HY168]
MIVLDCSALVDALTGVDGSQGLRHVLAEEELHAPELLDYEVVSAARGLTFGGHLSARRAEDLLLDFDDLPLHRWQASAGL
RRRAFTLRDNLSAYDAAYVALAEALRCPLVTRDARLCRSSGHEVEILMP

Download         Length: 390 bp

>T136059 NZ_CP042828:c4923339-4922950 [Ruania sp. HY168]
ATGATCGTCCTCGACTGCTCGGCCCTGGTCGATGCTCTGACCGGAGTGGACGGTAGTCAGGGGCTGCGACACGTACTCGC
CGAGGAGGAGTTGCACGCGCCGGAGCTGCTCGACTACGAGGTGGTCTCCGCAGCGCGTGGACTGACTTTTGGTGGCCACC
TCAGCGCCCGCCGCGCGGAGGATCTGCTACTCGACTTCGACGATCTGCCGCTGCACCGGTGGCAGGCCAGTGCGGGCTTG
CGGCGAAGGGCGTTCACGCTGCGGGACAACCTGAGTGCCTATGACGCAGCCTACGTCGCCTTGGCAGAGGCACTGCGGTG
CCCGCTGGTGACCCGGGACGCTCGGCTGTGCCGGTCGAGTGGGCATGAGGTCGAGATCCTCATGCCCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9683.91 Da        Isoelectric Point: 7.0212

>AT136059 WP_147919121.1 NZ_CP042828:c4923593-4923336 [Ruania sp. HY168]
MASLLQIRGVPEETRRELKARAAERGQSMNAYLLDLVTRETERPTVVEVLRRAERRAERADISAADIVATARAEREEHLA
RRGDE

Download         Length: 258 bp

>AT136059 NZ_CP042828:c4923593-4923336 [Ruania sp. HY168]
ATGGCTTCGTTGCTGCAGATCAGGGGCGTACCTGAGGAGACCAGGCGCGAACTGAAGGCGCGCGCCGCCGAGCGCGGTCA
GTCGATGAACGCTTATCTCCTGGATCTGGTCACTCGTGAGACCGAACGGCCGACTGTGGTCGAGGTGCTGCGTCGCGCCG
AGCGCCGTGCTGAGCGAGCAGACATCTCGGCGGCTGACATCGTGGCAACGGCCCGTGCTGAACGTGAGGAGCACCTGGCC
CGCCGGGGTGACGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References