Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 3674386..3675035 Replicon chromosome
Accession NZ_CP042828
Organism Ruania sp. HY168

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FU260_RS17065 Protein ID WP_147918138.1
Coordinates 3674386..3674805 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FU260_RS17070 Protein ID WP_147918139.1
Coordinates 3674802..3675035 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FU260_RS17040 3669516..3670718 + 1203 WP_147918134.1 hypothetical protein -
FU260_RS17045 3670901..3671806 + 906 WP_147918135.1 hypothetical protein -
FU260_RS17050 3672091..3673302 + 1212 WP_147918136.1 MFS transporter -
FU260_RS17055 3673302..3673991 + 690 WP_147918137.1 MerR family transcriptional regulator -
FU260_RS17060 3674168..3674353 - 186 WP_147919578.1 DUF86 domain-containing protein -
FU260_RS17065 3674386..3674805 - 420 WP_147918138.1 type II toxin-antitoxin system VapC family toxin Toxin
FU260_RS17070 3674802..3675035 - 234 WP_147918139.1 Arc family DNA-binding protein Antitoxin
FU260_RS17075 3675316..3676206 - 891 WP_147918140.1 NAD(P)H-binding protein -
FU260_RS17080 3676242..3676826 + 585 WP_147918141.1 TetR/AcrR family transcriptional regulator -
FU260_RS17085 3677015..3677848 - 834 WP_147918142.1 DUF4111 domain-containing protein -
FU260_RS17090 3677845..3678147 - 303 WP_147918143.1 HigA family addiction module antidote protein -
FU260_RS17095 3678134..3678415 - 282 WP_147918144.1 type II toxin-antitoxin system RelE/ParE family toxin -
FU260_RS17100 3678586..3679017 - 432 WP_210418114.1 DUF1801 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3663553..3678939 15386


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-130)

Antitoxin

Arc-like DNA binding domain

(11-41)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15183.19 Da        Isoelectric Point: 4.1369

>T136056 WP_147918138.1 NZ_CP042828:c3674805-3674386 [Ruania sp. HY168]
MIVLDTNVISEAFRPTPDPGVIEWLESLTDDVAITTITLAELLAGVRWLPDGRRKSDLEAALGAAIDPYRNTRSLLVFDD
EAAEEYAEVLFAREQAGLPISTPDAQIAAICRAHGAMCATRNEKDFAETGVRVLNPWTV

Download         Length: 420 bp

>T136056 NZ_CP042828:c3674805-3674386 [Ruania sp. HY168]
ATGATCGTTCTCGATACGAACGTCATCTCGGAGGCATTCCGGCCGACGCCTGATCCTGGTGTGATCGAGTGGCTCGAGTC
CCTCACTGACGACGTTGCGATCACGACGATCACACTCGCCGAATTGCTCGCGGGTGTGCGATGGCTGCCGGATGGTCGGC
GTAAGAGCGATTTGGAGGCGGCGCTCGGTGCCGCGATCGATCCCTACCGCAACACGCGTTCGCTTCTCGTGTTCGATGAT
GAGGCTGCTGAAGAGTATGCAGAAGTTCTGTTCGCTCGAGAACAAGCGGGGCTGCCGATCAGTACCCCTGATGCGCAGAT
CGCGGCGATCTGTCGAGCACATGGTGCGATGTGCGCCACGCGCAACGAAAAGGACTTTGCGGAGACAGGTGTTCGGGTTC
TGAACCCGTGGACTGTGTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8456.69 Da        Isoelectric Point: 7.2062

>AT136056 WP_147918139.1 NZ_CP042828:c3675035-3674802 [Ruania sp. HY168]
MSSIIVRGLDESVKDRLAAQAKEHGRSMEAEVRDILMRASLRPHIGIALMRVAREAGGAEELRIPERSDAARSVDFG

Download         Length: 234 bp

>AT136056 NZ_CP042828:c3675035-3674802 [Ruania sp. HY168]
ATGTCGTCGATCATCGTCCGCGGTCTTGATGAGTCTGTGAAAGACCGTCTGGCTGCGCAGGCAAAGGAACATGGCCGCTC
TATGGAAGCAGAGGTGCGCGACATCTTGATGCGTGCATCGTTGAGGCCGCACATCGGCATCGCGCTCATGCGTGTCGCCC
GCGAGGCCGGTGGCGCTGAGGAACTGCGGATTCCGGAACGGTCGGACGCCGCGCGTTCGGTAGATTTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References