Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1768808..1769463 Replicon chromosome
Accession NZ_CP042828
Organism Ruania sp. HY168

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FU260_RS08275 Protein ID WP_147916631.1
Coordinates 1769071..1769463 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FU260_RS08270 Protein ID WP_147916630.1
Coordinates 1768808..1769074 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FU260_RS08230 1763921..1764739 - 819 WP_147916623.1 hypothetical protein -
FU260_RS08235 1764758..1765189 - 432 WP_147919384.1 DUF1772 domain-containing protein -
FU260_RS08240 1765207..1765689 - 483 WP_168211701.1 nitroreductase family deazaflavin-dependent oxidoreductase -
FU260_RS08245 1765710..1766276 + 567 WP_147916625.1 TetR/AcrR family transcriptional regulator -
FU260_RS08250 1766287..1766835 + 549 WP_147916626.1 RNA 2',3'-cyclic phosphodiesterase -
FU260_RS08255 1766839..1767426 - 588 WP_147916627.1 hypothetical protein -
FU260_RS08260 1767480..1768541 + 1062 WP_147916628.1 ATP-dependent DNA ligase -
FU260_RS08265 1768538..1768765 + 228 WP_147916629.1 hypothetical protein -
FU260_RS08270 1768808..1769074 + 267 WP_147916630.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FU260_RS08275 1769071..1769463 + 393 WP_147916631.1 type II toxin-antitoxin system VapC family toxin Toxin
FU260_RS08280 1769476..1770522 - 1047 WP_147916632.1 non-homologous end-joining DNA ligase -
FU260_RS08285 1770630..1771721 - 1092 WP_147916633.1 PLP-dependent aminotransferase family protein -
FU260_RS08290 1771818..1772501 - 684 WP_147916634.1 DedA family protein -
FU260_RS08295 1772779..1773855 + 1077 WP_147916635.1 phenylalanine--tRNA ligase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-123)

Antitoxin

Antitoxin VapB-like

(1-87)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14161.03 Da        Isoelectric Point: 5.2387

>T136055 WP_147916631.1 NZ_CP042828:1769071-1769463 [Ruania sp. HY168]
VIVDTSALIAVLLGEDDAPVFARLLAARPVRISAATLVEARIVIESRVGPAARRRLEDLLHTIQAEVVPVDEEQAFVASE
AYRDYGRGSGHAAGLNFGDCFSYALATTRREELLYKGEDLGHTDIRRAAR

Download         Length: 393 bp

>T136055 NZ_CP042828:1769071-1769463 [Ruania sp. HY168]
GTGATCGTCGATACGTCGGCGCTCATCGCCGTGCTCCTCGGTGAGGATGACGCGCCGGTGTTCGCTCGGTTGTTGGCGGC
GCGTCCGGTGCGGATCTCGGCTGCGACGCTGGTGGAGGCGCGCATCGTGATCGAGAGCCGTGTCGGTCCGGCGGCACGAC
GACGACTGGAGGATCTGCTTCATACCATCCAGGCAGAGGTGGTGCCGGTGGACGAGGAGCAGGCGTTCGTGGCGAGTGAG
GCATACCGCGACTACGGCCGAGGCAGCGGCCACGCCGCGGGCCTGAATTTCGGTGACTGCTTCAGTTACGCCTTGGCGAC
GACCAGGCGCGAGGAACTTCTGTACAAGGGTGAGGACCTCGGTCACACCGATATCAGGCGAGCGGCCCGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9682.72 Da        Isoelectric Point: 4.4996

>AT136055 WP_147916630.1 NZ_CP042828:1768808-1769074 [Ruania sp. HY168]
MGLNIKNERTHALVRELADLTGASQTSAVEDAVRRRIEQVRSVDGVHDGTVAEVLRIATDFQHLLTDEQRLALADADSDL
YDDAGLPR

Download         Length: 267 bp

>AT136055 NZ_CP042828:1768808-1769074 [Ruania sp. HY168]
ATGGGCCTCAACATTAAGAACGAGCGCACTCACGCACTGGTCAGAGAGTTGGCGGATCTCACCGGCGCCAGCCAGACCAG
CGCAGTGGAGGATGCCGTGCGTCGACGGATTGAGCAGGTGCGGTCCGTCGACGGTGTGCACGACGGCACTGTCGCCGAGG
TCCTGCGTATTGCTACGGACTTTCAACACCTCCTCACTGACGAGCAGCGTCTGGCATTGGCTGATGCCGACAGTGACCTC
TACGACGACGCGGGGCTGCCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References