Detailed information of TA system TA136054

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PHD(antitoxin)
• Location: 239822..240490
• Replicon: chromosome
• Accession: NZ_CP042828
• Organism: Ruania sp. HY168

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FU260_RS01360
• Protein ID: WP_147915432.1
• Coordinates: 239822..240223 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FU260_RS01365
• Protein ID: WP_147915433.1
• Coordinates: 240227..240490 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FU260_RS01355	239214..239699	+	486	WP_147915431.1	hypothetical protein	-
FU260_RS01360	239822..240223	-	402	WP_147915432.1	type II toxin-antitoxin system VapC family toxin	Toxin
FU260_RS01365	240227..240490	-	264	WP_147915433.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
FU260_RS01370	240509..241045	-	537	WP_147915434.1	DUF2220 domain-containing protein	-
FU260_RS01375	241090..242406	+	1317	WP_147915435.1	dicarboxylate/amino acid:cation symporter	-
FU260_RS01380	242525..243557	-	1033	Protein_235	DnaJ domain-containing protein	-
FU260_RS01385	243667..245070	-	1404	WP_147919255.1	lipase maturation factor family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-118)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-39)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 13880.68 Da
• Isoelectric Point: 4.8218

>T136054 WP_147915432.1 NZ_CP042828:c240223-239822 [Ruania sp. HY168]
VAHYVDTSALVKLVVAEAETPALRAWLGEQSRDPVTSDLTRTELVHAVRRVAPDRVVAARDVLDALTILSLSAHTFDSAA
TLAPSALRSLDAVHLASALTLGDDLDAIVSYDDRLSTAATALGVRALAPGAQS

Nucleotide

• Length: 402 bp

>T136054 NZ_CP042828:c240223-239822 [Ruania sp. HY168]
GTGGCGCACTATGTGGATACTTCGGCGCTGGTGAAACTCGTCGTCGCTGAGGCCGAGACTCCTGCGCTTCGCGCGTGGCT
GGGCGAGCAGTCTCGCGATCCGGTGACCTCCGACCTCACCCGCACGGAGTTGGTGCACGCCGTACGACGAGTTGCACCCG
ACCGGGTGGTAGCCGCCCGGGACGTCCTCGATGCACTCACCATCCTCAGTCTGTCGGCACACACCTTCGACTCCGCCGCC
ACGCTCGCGCCATCGGCTCTGCGCAGCCTGGACGCCGTCCACCTGGCCAGCGCCCTCACCCTCGGCGACGATCTCGACGC
CATCGTCAGCTACGACGACCGCCTCAGCACGGCTGCGACGGCACTCGGAGTGCGCGCACTGGCGCCGGGTGCGCAGTCGT
GA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9223.63 Da
• Isoelectric Point: 10.7849

>AT136054 WP_147915433.1 NZ_CP042828:c240490-240227 [Ruania sp. HY168]
MAKVGVRALKQNASAVVRGVVAGERVVITDRGRAVAQLTALPTSPLQTLRDAGLARPPRGRIEDLPAPAPGPQISETLAQ
MRDEEPY

Nucleotide

• Length: 264 bp

>AT136054 NZ_CP042828:c240490-240227 [Ruania sp. HY168]
ATGGCGAAGGTAGGAGTTCGGGCACTCAAGCAGAACGCATCGGCCGTGGTGCGCGGCGTGGTCGCAGGCGAACGCGTGGT
CATCACCGATCGGGGGCGTGCGGTGGCTCAACTGACCGCACTGCCGACGTCTCCGTTACAGACTCTTCGGGACGCTGGCC
TCGCCCGGCCCCCTCGCGGGCGAATCGAGGATCTGCCGGCACCGGCACCGGGCCCGCAGATCTCCGAGACTCTTGCCCAG
ATGCGCGACGAAGAGCCCTACTGA