136047

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 138605..140091 Replicon plasmid unnamed2
Accession NZ_CP042825
Organism Rhizobium sp. WL3

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag FVA81_RS01035 Protein ID WP_147884853.1
Coordinates 138829..140091 (+) Length 421 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag FVA81_RS01030 Protein ID WP_029620520.1
Coordinates 138605..138832 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FVA81_RS01020 135467..135661 - 195 Protein_123 transmembrane anchor protein -
FVA81_RS01025 135717..137957 - 2241 WP_147884852.1 GGDEF and EAL domain-containing protein -
FVA81_RS01030 138605..138832 + 228 WP_029620520.1 helix-turn-helix transcriptional regulator Antitoxin
FVA81_RS01035 138829..140091 + 1263 WP_147884853.1 type II toxin-antitoxin system HipA family toxin Toxin
FVA81_RS01040 140344..142110 - 1767 WP_147884854.1 extracellular solute-binding protein -
FVA81_RS01045 142163..143065 - 903 WP_147884855.1 NAD(P)-dependent oxidoreductase -
FVA81_RS01050 143525..144598 + 1074 WP_147884856.1 2,3-butanediol dehydrogenase -
FVA81_RS01055 144739..145023 + 285 WP_147884857.1 YciI family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - gmd 1..700631 700631


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-48)


Sequences

Toxin        


Download         Length: 421 a.a.        Molecular weight: 45743.53 Da        Isoelectric Point: 5.5155

>T136047 WP_147884853.1 NZ_CP042825:138829-140091 [Rhizobium sp. WL3]
MTRVLDVYFRDTKAGVLGRLDDGLLTFAYDGAYLLDQRSRAISFSMPLQEEPFGDQVVRPFFSGLLPDEGARQRLAGALG
LSAGNAFGLLEVIGGECAGALSLYPTGTVPPPSGQSQAEILTSERLDEILSRLRTRPLLGGDEGIRLSLAGAQDKLAVIV
DGDSIALARNGRPTTHILKPVIQALEGTVENEYFCMRLAARLKLPVPHVEIRLDGATAFLLVERYDRTKAADGIIERLHQ
EDFCQALSVPPELKYEAEGGPGTERALGLIDQACARPVADRLQFIRMLIFHYLVGNADAHGKNYALLYGSDEPDLAPIYD
VVCTAVYPRLSKRLAMKIGGRDVPDTVQLKHWKALVPDTKSSQRILVRDLAQMAERIVSEADTLVAELAEEGINHPILSA
IRKVIASRAGLLQRAAEQVS

Download         Length: 1263 bp

>T136047 NZ_CP042825:138829-140091 [Rhizobium sp. WL3]
ATGACCCGCGTATTGGATGTCTATTTTCGCGACACCAAAGCGGGCGTACTCGGCCGGCTTGACGACGGCCTGCTGACTTT
TGCCTATGATGGCGCGTATCTCCTGGACCAACGATCGCGTGCGATCTCGTTCTCGATGCCCCTGCAAGAAGAACCCTTTG
GTGATCAGGTGGTGCGCCCGTTTTTCTCCGGTCTCTTGCCGGACGAGGGCGCGCGGCAACGCCTCGCTGGGGCGCTCGGC
CTTTCGGCAGGCAATGCCTTCGGGCTATTGGAAGTTATCGGGGGCGAGTGCGCAGGTGCCTTGTCACTCTATCCTACAGG
CACGGTGCCCCCACCTTCTGGCCAGTCCCAGGCCGAAATTCTCACTTCGGAACGTCTGGATGAAATTCTAAGCAGGCTGC
GGACCCGGCCTTTGCTTGGTGGAGACGAGGGCATTCGCCTATCGCTCGCCGGCGCGCAGGATAAACTGGCGGTCATTGTC
GATGGAGATTCCATTGCCTTGGCGAGAAATGGTCGACCAACGACCCATATCTTGAAACCGGTCATCCAGGCGCTGGAAGG
CACAGTGGAGAACGAGTATTTCTGTATGCGGCTGGCTGCCCGCCTCAAGCTGCCGGTACCCCATGTCGAGATACGCCTAG
ACGGGGCGACTGCCTTTCTCCTGGTTGAACGTTACGATCGGACGAAGGCTGCAGACGGCATCATTGAGCGCCTACACCAG
GAAGACTTTTGCCAGGCCCTTAGCGTACCGCCGGAACTGAAGTATGAGGCCGAGGGCGGACCGGGAACAGAACGGGCTCT
CGGGCTGATCGACCAGGCCTGCGCGAGGCCCGTCGCGGATCGGTTGCAGTTCATCCGCATGCTGATCTTCCACTATCTCG
TCGGCAACGCCGATGCCCACGGCAAGAACTACGCCCTGCTGTACGGCTCCGATGAACCGGATCTGGCACCGATCTACGAT
GTCGTTTGCACGGCCGTTTATCCTCGCTTGTCAAAGAGGCTCGCCATGAAGATTGGCGGCCGCGATGTGCCCGACACCGT
CCAGCTGAAGCATTGGAAGGCATTGGTGCCCGATACTAAATCTTCCCAGCGCATCCTTGTTCGCGATCTTGCCCAGATGG
CGGAAAGGATTGTGAGCGAGGCCGATACCCTTGTTGCAGAACTGGCCGAAGAGGGGATCAATCATCCCATCCTGAGTGCA
ATTCGCAAGGTCATCGCAAGTCGGGCTGGTTTGCTACAGAGAGCCGCGGAGCAGGTGTCTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8191.63 Da        Isoelectric Point: 11.2138

>AT136047 WP_029620520.1 NZ_CP042825:138605-138832 [Rhizobium sp. WL3]
MEKIKDTKSLGMLIRQERKQQGLTQEQLAGVIGVGVRFLRELEAGKESCQIGRAMQVLAGLGLVVSVGRRQGPRS

Download         Length: 228 bp

>AT136047 NZ_CP042825:138605-138832 [Rhizobium sp. WL3]
ATGGAAAAGATCAAAGATACAAAAAGCCTTGGCATGCTGATCCGTCAGGAGCGCAAACAGCAAGGATTAACCCAGGAGCA
ACTCGCCGGGGTGATTGGTGTGGGCGTACGGTTTCTGCGTGAACTCGAGGCTGGCAAAGAGAGCTGCCAGATTGGCCGTG
CGATGCAAGTCCTGGCTGGTTTGGGCCTCGTTGTTTCGGTCGGTCGTCGCCAGGGTCCGCGATCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References