Detailed information of TA system TA136046

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 5894954..5895516
• Replicon: chromosome
• Accession: NZ_CP042823
• Organism: Methylobacterium sp. WL1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FVA80_RS28690
• Protein ID: WP_147910324.1
• Coordinates: 5894954..5895325 (-)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FVA80_RS28695
• Protein ID: WP_147853926.1
• Coordinates: 5895322..5895516 (-)
• Length: 65 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FVA80_RS28675	5891709..5892509	+	801	WP_147910327.1	phosphorylase	-
FVA80_RS28680	5892678..5894219	-	1542	WP_147910326.1	Do family serine endopeptidase	-
FVA80_RS28685	5894552..5894929	+	378	WP_147910325.1	hypothetical protein	-
FVA80_RS28690	5894954..5895325	-	372	WP_147910324.1	type II toxin-antitoxin system VapC family toxin	Toxin
FVA80_RS28695	5895322..5895516	-	195	WP_147853926.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
FVA80_RS28700	5896109..5898826	-	2718	WP_147910323.1	valine--tRNA ligase	-
FVA80_RS28705	5898941..5899469	-	529	Protein_5590	DUF2497 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-112)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-42)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13468.57 Da
• Isoelectric Point: 5.8883

>T136046 WP_147910324.1 NZ_CP042823:c5895325-5894954 [Methylobacterium sp. WL1]
VIIIDTNIWIDHLAATDPSVTAILTDMSQRVHPFVIGELALGSIRDRERVIATLEDMPPADVAAHDEVMLLIAEHALHGL
GIGYVDAHLLASAKLMPGSRIWTRDRRLAAVSERLGVSYRAVQ

Nucleotide

• Length: 372 bp

>T136046 NZ_CP042823:c5895325-5894954 [Methylobacterium sp. WL1]
GTGATCATCATCGATACGAACATCTGGATCGATCACCTCGCGGCGACGGATCCATCCGTCACCGCGATCCTGACCGACAT
GAGCCAGCGTGTTCATCCCTTCGTCATCGGCGAACTGGCGCTGGGCAGCATCCGCGACCGCGAACGCGTCATCGCGACCC
TGGAAGACATGCCGCCGGCCGACGTCGCGGCCCACGATGAAGTCATGCTCCTGATCGCGGAGCACGCGTTGCACGGCCTC
GGCATCGGCTATGTGGACGCACATCTCCTGGCATCGGCGAAGCTGATGCCGGGCTCCCGAATATGGACACGCGACAGACG
CCTGGCCGCGGTGAGCGAACGGCTCGGGGTGTCATACCGAGCGGTCCAGTAG

Antitoxin

Protein

• Length: 65 a.a.
• Molecular weight: 7168.10 Da
• Isoelectric Point: 10.1988

>AT136046 WP_147853926.1 NZ_CP042823:c5895516-5895322 [Methylobacterium sp. WL1]
MRTTINLDDDLLAKAQHYTGITEKSELVREALRALVQREASRRMILLGGSDSNAQAGTRRRSEP

Nucleotide

• Length: 195 bp

>AT136046 NZ_CP055224:c4084749-4084483 [Pectobacterium atrosepticum]
ATGGAAATCGATAATAAATCACGCATTCATTGGGCATGCCGCCGTGGTATGCGTGAACTGGATATCGCGATCATGCCGTT
TTTTGAGCATGACTATGACACACTTAATGACAGTGATAAGCGCGCGTTTGTACGCCTGTTACAAAGCGACGATCCCGATT
TATTCAACTGGCTGATGAACCACGGTGAACCGAAGGACGGAGAGTTGAAACGTATGATTTCCCTTATTCAGACGCGAAAT
AAAGACCGTGGCCCAGTGGCAATGTGA