Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 5624230..5624804 Replicon chromosome
Accession NZ_CP042823
Organism Methylobacterium sp. WL1

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag FVA80_RS27420 Protein ID WP_147906339.1
Coordinates 5624514..5624804 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag FVA80_RS27415 Protein ID WP_147906338.1
Coordinates 5624230..5624511 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FVA80_RS27400 5619880..5623203 + 3324 WP_147906335.1 PAS domain-containing protein -
FVA80_RS27405 5623211..5623516 - 306 WP_147906336.1 hypothetical protein -
FVA80_RS27410 5623513..5623824 - 312 WP_147906337.1 EthD family reductase -
FVA80_RS27415 5624230..5624511 - 282 WP_147906338.1 putative addiction module antidote protein Antitoxin
FVA80_RS27420 5624514..5624804 - 291 WP_147906339.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FVA80_RS27425 5624950..5626281 - 1332 WP_147906418.1 NAD(P)/FAD-dependent oxidoreductase -
FVA80_RS27430 5626405..5627052 - 648 WP_147906340.1 maleylacetoacetate isomerase -
FVA80_RS27435 5627211..5628149 - 939 WP_147906341.1 aspartate/glutamate racemase family protein -
FVA80_RS27440 5628993..5629550 + 558 WP_147906342.1 molybdenum cofactor biosynthesis protein B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10750.33 Da        Isoelectric Point: 10.3397

>T136045 WP_147906339.1 NZ_CP042823:c5624804-5624514 [Methylobacterium sp. WL1]
MFQVRRTGEFIAWLNALREVQARARITKRIDRIAQGNLGDAKSVGDGVSELRFSFGPGYRVYYTLRGDVVVILLCGGDKG
SQTQDIERAKTMAREV

Download         Length: 291 bp

>T136045 NZ_CP055224:3981188-3981472 [Pectobacterium atrosepticum]
ATGAGTTATAAGCTGGAGTTTGAAGAGCACGCGCTGAAAGAATTTAAGAAGCTGGGTGCACCCGTGCGGGAGCTGTTCAC
CAAAAAGCTGAAAGCGGTTTTACAAAATCCCCACGTTCCCGCCAACCGACTTCATGGAATGGCTGACTGCTACAAAATCA
AACTTCGTTCCGCTGGCTATCGGCTAGTGTATCAAGTGCTTGAGCATGAGATCGTAGTACTGGTTTTAGCTGTGGGCAAG
CGTGAACGCTCAGAGGTTTATCAAGCAGCCAAAGACCGACTATAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 9927.32 Da        Isoelectric Point: 4.5535

>AT136045 WP_147906338.1 NZ_CP042823:c5624511-5624230 [Methylobacterium sp. WL1]
MAIETKPWDAAEVLRTPADIAAYLDAYLEDGTPEELLGALNTIARSHGMSALARETGISREALYKAFSDNGNPTLDTLLR
VLKALGVRLAVAA

Download         Length: 282 bp

>AT136045 NZ_CP055224:3980947-3981198 [Pectobacterium atrosepticum]
ATGTCCGTGCAACCTATTCTTGCCAATGCTGCCGTGAGTATTAGCGACTTTAAAAAATCGCCCAATGCAGCGTTGAAAGA
AGCTAACGGCGAGCCTGTAGCCGTGTTAACCAATGGCCGTATCTCTGGCTATTATGTTTCCCCGGAAACATGGGAAGCGC
TGGCCGACTATCAGGAAGATATCGAACTTGCCAAAATTGCCCGCTCCCGGATGAAGGGGAAACGTGTGAAGGTCGATCTG
GATGAGTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References