Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5528261..5528945 Replicon chromosome
Accession NZ_CP042823
Organism Methylobacterium sp. WL1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag FVA80_RS26990 Protein ID WP_147910952.1
Coordinates 5528736..5528945 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag FVA80_RS26985 Protein ID WP_147910953.1
Coordinates 5528261..5528665 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FVA80_RS26960 5524040..5524597 - 558 WP_147910921.1 gluconokinase -
FVA80_RS26965 5524793..5525044 + 252 WP_147910920.1 DUF3072 domain-containing protein -
FVA80_RS26970 5525360..5525602 + 243 WP_147910919.1 hypothetical protein -
FVA80_RS26975 5525782..5526951 + 1170 WP_147957905.1 polysaccharide export protein -
FVA80_RS26980 5527114..5528250 + 1137 WP_147910954.1 branched-chain amino acid ABC transporter substrate-binding protein -
FVA80_RS26985 5528261..5528665 - 405 WP_147910953.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FVA80_RS26990 5528736..5528945 - 210 WP_147910952.1 type II toxin-antitoxin system HicA family toxin Toxin
FVA80_RS26995 5529147..5529713 - 567 WP_147910951.1 protein-tyrosine-phosphatase -
FVA80_RS27000 5529928..5531058 + 1131 WP_147910152.1 TRAP transporter substrate-binding protein DctP -
FVA80_RS27005 5531219..5532631 + 1413 WP_147910153.1 phosphatase PAP2 family protein -
FVA80_RS27010 5532652..5533636 - 985 Protein_5253 NAD(P)H-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(13-67)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(7-126)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7856.01 Da        Isoelectric Point: 11.3225

>T136044 WP_147910952.1 NZ_CP042823:c5528945-5528736 [Methylobacterium sp. WL1]
MSKKVRDRTTRGVIAALQRDGWFVARKGPGDHVQFKYPRKPGKVTVDTGEPEIPTGTLRSIYRQAGWTW

Download         Length: 210 bp

>T136044 NZ_CP042823:c5528945-5528736 [Methylobacterium sp. WL1]
ATGTCGAAGAAGGTGCGTGACCGCACAACACGCGGGGTGATCGCGGCGCTTCAGAGGGACGGTTGGTTCGTCGCTCGGAA
GGGACCCGGCGATCACGTCCAGTTCAAGTATCCGAGAAAGCCCGGAAAAGTCACAGTCGATACCGGCGAGCCGGAAATAC
CGACTGGAACCCTACGTAGTATCTATCGGCAGGCTGGATGGACTTGGTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14345.34 Da        Isoelectric Point: 4.8001

>AT136044 WP_147910953.1 NZ_CP042823:c5528665-5528261 [Methylobacterium sp. WL1]
MAHVVMLVHQEDGRFGASFPDFPGATTVAGDLDTLYRKAAEMLAFHVAGMAKDGEEIPRLRALEELRGDPGFCEDSADAM
VALMQVELPGRAVRVNISMEEGLLRRIDRAAEATGESRSAFLAQAAKARLSAGA

Download         Length: 405 bp

>AT136044 NZ_CP042823:c5528665-5528261 [Methylobacterium sp. WL1]
ATGGCTCACGTTGTCATGCTGGTGCACCAGGAGGACGGCCGGTTCGGCGCCTCCTTCCCGGACTTCCCGGGAGCGACGAC
GGTCGCGGGCGATCTCGACACGCTCTATCGGAAGGCCGCCGAGATGTTGGCCTTCCACGTCGCCGGAATGGCGAAGGACG
GTGAAGAGATCCCGCGCCTGCGGGCACTGGAGGAATTGCGCGGCGACCCGGGCTTTTGCGAGGACAGCGCCGACGCGATG
GTCGCGCTCATGCAGGTCGAGCTTCCAGGCCGGGCCGTGCGCGTCAACATCTCAATGGAGGAAGGCCTCCTCCGACGGAT
CGACCGGGCCGCCGAGGCGACCGGCGAGAGCCGATCCGCCTTTCTGGCTCAAGCCGCGAAGGCGCGGCTATCGGCCGGGG
CTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References