Detailed information of TA system TA136039

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 905916..906441
• Replicon: chromosome
• Accession: NZ_CP042812
• Organism: Malaciobacter canalis strain LMG 29148

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: ACAN_RS04485
• Protein ID: WP_099333964.1
• Coordinates: 906157..906441 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: ACAN_RS04480
• Protein ID: WP_099333963.1
• Coordinates: 905916..906173 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ACAN_RS04460	901258..902115	+	858	WP_196778770.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
ACAN_RS04465	902112..903674	+	1563	WP_099333960.1	alginate lyase family protein	-
ACAN_RS04470	903671..904834	+	1164	WP_099333961.1	glycosyltransferase family 4 protein	-
ACAN_RS04475	904831..905781	+	951	WP_099333962.1	NAD-dependent epimerase/dehydratase family protein	-
ACAN_RS04480	905916..906173	+	258	WP_099333963.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
ACAN_RS04485	906157..906441	+	285	WP_099333964.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ACAN_RS04490	906748..907005	+	258	WP_099333965.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
ACAN_RS04495	906996..907250	+	255	WP_099333966.1	Txe/YoeB family addiction module toxin	-
ACAN_RS04500	907250..908212	+	963	WP_099333967.1	glycosyltransferase family 4 protein	-
ACAN_RS04505	908326..910056	+	1731	WP_099333968.1	UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining)	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (10-74)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11241.14 Da
• Isoelectric Point: 10.2633

>T136039 WP_099333964.1 NZ_CP042812:906157-906441 [Malaciobacter canalis]
MSYFLDFHPKALKEWKSLNHSIKVQFHKKLKERLENPKIPKDKLSGYDNVYKIKLRNIGYGLAYEVKEKEIIVYVVSVGK
RENNKVYENLKDRV

Nucleotide

• Length: 285 bp

>T136039 NZ_CP042812:906157-906441 [Malaciobacter canalis]
ATGAGCTACTTTCTTGATTTTCATCCAAAAGCTTTAAAAGAATGGAAAAGTCTAAATCACTCCATAAAAGTACAGTTTCA
TAAAAAATTAAAAGAGCGACTTGAAAATCCAAAAATACCAAAAGATAAACTCAGCGGTTATGATAATGTTTATAAAATTA
AACTTCGTAATATTGGTTATGGGCTAGCGTATGAAGTAAAAGAGAAAGAAATAATAGTCTATGTTGTGAGTGTAGGAAAA
AGAGAAAACAATAAAGTATATGAGAATTTGAAAGATAGAGTATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9676.10 Da
• Isoelectric Point: 4.4929

>AT136039 WP_099333963.1 NZ_CP042812:905916-906173 [Malaciobacter canalis]
MQPVLANYTASITELKKSPTQLLKDAGDETVAILNHNVASAYLVPSSVYKKMMEVMDEYYLSKEVEERLKDNEKPIRVEL
DELLS

Nucleotide

• Length: 258 bp

>AT136039 NZ_CP042812:905916-906173 [Malaciobacter canalis]
ATGCAACCTGTATTAGCAAATTATACAGCAAGTATAACAGAACTGAAAAAATCACCAACACAGCTACTAAAAGATGCAGG
TGATGAAACAGTGGCGATACTTAATCACAATGTAGCAAGTGCTTATTTAGTACCTAGTAGTGTGTATAAAAAAATGATGG
AAGTTATGGATGAATATTATTTGAGTAAAGAAGTGGAAGAGAGGCTCAAAGACAATGAAAAACCAATAAGAGTAGAACTA
GATGAGCTACTTTCTTGA