Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2441889..2442524 Replicon chromosome
Accession NZ_CP042808
Organism Acetobacter oryzoeni strain B6

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EOV40_RS11405 Protein ID WP_128106012.1
Coordinates 2441889..2442299 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EOV40_RS11410 Protein ID WP_128106013.1
Coordinates 2442300..2442524 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EOV40_RS11390 2437670..2438866 - 1197 WP_196778589.1 ATP-binding protein -
EOV40_RS11395 2439360..2440558 - 1199 Protein_2193 MFS transporter -
EOV40_RS11400 2440712..2441602 + 891 WP_087607217.1 LysR family transcriptional regulator -
EOV40_RS11405 2441889..2442299 - 411 WP_128106012.1 tRNA(fMet)-specific endonuclease VapC Toxin
EOV40_RS11410 2442300..2442524 - 225 WP_128106013.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
EOV40_RS11415 2442779..2443129 + 351 WP_128106014.1 hypothetical protein -
EOV40_RS11420 2443388..2444341 + 954 Protein_2198 glutathione S-transferase family protein -
EOV40_RS11425 2444385..2445008 + 624 WP_128106015.1 dienelactone hydrolase family protein -
EOV40_RS11430 2445020..2445934 + 915 WP_086641002.1 LysR family transcriptional regulator -
EOV40_RS11435 2445942..2446622 - 681 WP_128106016.1 flavin reductase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2379325..2447669 68344


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(9-55)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15530.74 Da        Isoelectric Point: 6.4680

>T136034 WP_128106012.1 NZ_CP042808:c2442299-2441889 [Acetobacter oryzoeni]
MLRYLLDTNLCIRVLRDRPQGLRPRFNSCAEELCISDVVLYELLYGAERSSDPVRTRREVERFAARLAVLPFDSEAAAHT
ADIRAELERNGRIIGPYDLMIAGHARSRGLIVVTGNLREFQRVEGLRTEDWLTDTA

Download         Length: 411 bp

>T136034 NZ_CP055219:2249558-2250022 [Shigella flexneri]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8203.36 Da        Isoelectric Point: 4.9622

>AT136034 WP_128106013.1 NZ_CP042808:c2442524-2442300 [Acetobacter oryzoeni]
MLTRTTLFLSNRSQAVRLPKMVAFGEQVRDVVIVSEGSRRIIAPADAAWDDFFAAPGVDLGERNQPAMQDREAL

Download         Length: 225 bp

>AT136034 NZ_CP042808:c2442524-2442300 [Acetobacter oryzoeni]
ATGCTGACCCGTACGACACTCTTTCTATCCAACCGCTCGCAGGCAGTGCGCCTGCCGAAGATGGTCGCCTTCGGGGAGCA
GGTGCGTGACGTCGTCATTGTGTCCGAAGGTTCACGACGCATCATCGCCCCCGCTGACGCAGCGTGGGATGATTTCTTTG
CGGCTCCCGGCGTGGATCTGGGGGAGCGGAACCAGCCGGCCATGCAGGACCGTGAGGCGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References