Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 5772720..5773359 Replicon chromosome
Accession NZ_CP042804
Organism Pseudomonas amygdali pv. tabaci str. ATCC 11528

Toxin (Protein)


Gene name hicA Uniprot ID A0A7Z6Y3C5
Locus tag PSYTB_RS27085 Protein ID WP_005781617.1
Coordinates 5773177..5773359 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0Q0DRU8
Locus tag PSYTB_RS27080 Protein ID WP_016981256.1
Coordinates 5772720..5773145 (-) Length 142 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSYTB_RS27065 5769186..5770508 + 1323 WP_039847354.1 murein hydrolase activator EnvC -
PSYTB_RS27070 5770542..5771879 + 1338 WP_002551463.1 S41 family peptidase -
PSYTB_RS27075 5771883..5772665 + 783 WP_004655075.1 divergent polysaccharide deacetylase family protein -
PSYTB_RS27080 5772720..5773145 - 426 WP_016981256.1 transcriptional regulator Antitoxin
PSYTB_RS27085 5773177..5773359 - 183 WP_005781617.1 type II toxin-antitoxin system HicA family toxin Toxin
PSYTB_RS27090 5773686..5773984 + 299 Protein_5019 serine protease -
PSYTB_RS27095 5773989..5774744 - 756 WP_004663214.1 ABC transporter substrate-binding protein -
PSYTB_RS27100 5774930..5775700 - 771 WP_002551458.1 imidazole glycerol phosphate synthase subunit HisF -
PSYTB_RS27105 5775720..5776457 - 738 WP_002551457.1 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase -
PSYTB_RS27110 5776565..5776825 - 261 WP_002551456.1 DUF2164 domain-containing protein -
PSYTB_RS27115 5776830..5777468 - 639 WP_005745046.1 imidazole glycerol phosphate synthase subunit HisH -
PSYTB_RS27120 5777468..5778061 - 594 WP_002551454.1 imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-58)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6877.97 Da        Isoelectric Point: 10.6211

>T136030 WP_005781617.1 NZ_CP042804:c5773359-5773177 [Pseudomonas amygdali pv. tabaci str. ATCC 11528]
MKCNEFRRWLQAQGAEFRAAKGSHFKVYLNGKATIFADHGSKEMHEGLRKSIIKQLGLKD

Download         Length: 183 bp

>T136030 NZ_CP042804:c5773359-5773177 [Pseudomonas amygdali pv. tabaci str. ATCC 11528]
ATGAAGTGCAACGAGTTTCGGCGATGGTTGCAGGCTCAAGGCGCTGAGTTCAGGGCTGCCAAGGGTAGTCATTTCAAGGT
TTACCTGAATGGTAAGGCAACCATCTTTGCAGACCATGGAAGCAAAGAAATGCACGAAGGGTTACGCAAGTCGATCATCA
AGCAGCTCGGCCTTAAGGATTGA

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15783.24 Da        Isoelectric Point: 5.2548

>AT136030 WP_016981256.1 NZ_CP042804:c5773145-5772720 [Pseudomonas amygdali pv. tabaci str. ATCC 11528]
MYQYPLDLHREPTGVWLSCPDIPEMSASGDTLPEAFSEALDGMESALSLYVDQRRKIPQASVVPGHELLMRLPALTVAKI
MLWNSLLEEGVSRAELARRLGCTRQVVDRLVDFLHASKIEQVERALAELGRRITLSIERAA

Download         Length: 426 bp

>AT136030 NZ_CP042804:c5773145-5772720 [Pseudomonas amygdali pv. tabaci str. ATCC 11528]
ATGTATCAATATCCATTGGATCTACATCGGGAGCCGACAGGCGTTTGGCTGTCGTGTCCAGACATTCCCGAAATGAGCGC
CTCTGGCGACACCCTGCCTGAAGCATTTAGCGAAGCTCTTGACGGCATGGAATCGGCTCTATCGCTCTACGTCGATCAGC
GTCGCAAGATTCCCCAAGCCTCAGTCGTACCCGGCCATGAACTGTTGATGCGTTTGCCTGCGCTGACGGTTGCCAAAATC
ATGCTATGGAACAGCTTGTTGGAAGAGGGCGTTAGCCGTGCTGAGCTGGCGCGTCGCCTCGGTTGCACGCGGCAAGTGGT
GGATCGGCTTGTGGACTTTCTGCATGCCTCGAAAATCGAGCAGGTGGAGCGAGCGCTGGCTGAGCTTGGTCGGCGTATTA
CGTTGAGCATTGAGCGGGCCGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z6Y3C5

Antitoxin

Source ID Structure
AlphaFold DB A0A0Q0DRU8

References