Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 886194..886786 Replicon chromosome
Accession NZ_CP042652
Organism Pseudoarcobacter acticola strain KCTC 52212

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag AACT_RS04565 Protein ID WP_172125381.1
Coordinates 886194..886442 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag AACT_RS04570 Protein ID WP_172125383.1
Coordinates 886442..886786 (+) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AACT_RS04545 881332..881979 + 648 WP_172125373.1 endonuclease III -
AACT_RS04550 882012..882422 - 411 WP_172125375.1 hypothetical protein -
AACT_RS04555 882503..884095 + 1593 WP_172125377.1 glycerol-3-phosphate dehydrogenase/oxidase -
AACT_RS04560 884181..886151 + 1971 WP_172125379.1 TonB-dependent receptor -
AACT_RS04565 886194..886442 + 249 WP_172125381.1 type II toxin-antitoxin system HicA family toxin Toxin
AACT_RS04570 886442..886786 + 345 WP_172125383.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
AACT_RS04575 886828..888054 - 1227 WP_172125385.1 HD domain-containing protein -
AACT_RS04580 888301..889281 + 981 WP_172125387.1 DUF2156 domain-containing protein -
AACT_RS04585 889278..889709 + 432 WP_172125389.1 GNAT family N-acetyltransferase -
AACT_RS04590 889719..890174 - 456 WP_172125391.1 ribose 5-phosphate isomerase B -
AACT_RS04595 890174..890959 - 786 WP_172125393.1 signal peptidase I -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-78)

Antitoxin

Uncharacterised protein family HicB

(55-104)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9511.39 Da        Isoelectric Point: 10.3229

>T136024 WP_172125381.1 NZ_CP042652:886194-886442 [Pseudoarcobacter acticola]
MSKQNKLISKFLEIPPKKDLTFKELSSLLLSLNFEKIEGAGSAVKFYNKEKDLLINLHKPHPSDILKVYLVKQIQIKLKE
FI

Download         Length: 249 bp

>T136024 NZ_CP042652:886194-886442 [Pseudoarcobacter acticola]
ATGAGTAAACAAAATAAACTTATTTCAAAGTTTTTGGAAATTCCTCCAAAAAAAGATTTAACTTTCAAAGAGTTAAGTTC
ATTACTATTATCATTGAATTTTGAAAAAATTGAAGGAGCAGGTTCTGCTGTGAAATTTTATAATAAAGAAAAAGATTTAT
TAATAAATTTACATAAGCCACATCCCTCAGATATTCTAAAAGTTTATCTTGTTAAGCAAATACAAATTAAATTAAAGGAG
TTTATCTGA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13070.66 Da        Isoelectric Point: 4.9505

>AT136024 WP_172125383.1 NZ_CP042652:886442-886786 [Pseudoarcobacter acticola]
MSNKIEYNGYIGTVEYSQEDKCFFGKLEMINDLVTFEAENASDLENNFKNSVDEYLKTCEELGREPQKAFKGVFNVRTGS
ELHLTAVRNAHKMGVSLNSYIKNLIERDTKISFN

Download         Length: 345 bp

>AT136024 NZ_CP042652:886442-886786 [Pseudoarcobacter acticola]
ATGTCTAATAAGATTGAATACAATGGATATATTGGTACAGTTGAATATTCTCAAGAAGATAAATGTTTTTTTGGTAAATT
AGAAATGATAAATGATCTAGTGACTTTTGAAGCTGAAAATGCTTCTGATCTAGAAAATAATTTTAAAAATTCAGTTGATG
AGTATTTAAAAACTTGCGAAGAATTAGGACGAGAACCGCAGAAGGCATTTAAAGGTGTTTTCAATGTAAGAACAGGAAGT
GAACTTCATCTTACAGCAGTTAGAAATGCTCATAAAATGGGTGTTTCTCTTAATTCATATATAAAAAATCTAATAGAAAG
AGATACAAAAATATCTTTTAATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References