136023

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF-doc
Location 18905..19509 Replicon plasmid unnamed
Accession NZ_CP042651
Organism Staphylococcus aureus strain X22

Toxin (Protein)


Gene name pemK Uniprot ID L7PFJ6
Locus tag FTD94_RS14825 Protein ID WP_001022435.1
Coordinates 19171..19509 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID L7PH55
Locus tag FTD94_RS14820 Protein ID WP_001129937.1
Coordinates 18905..19174 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FTD94_RS14805 15979..16377 + 399 WP_044290589.1 hypothetical protein -
FTD94_RS14810 16681..17412 - 732 WP_015379487.1 CPBP family intramembrane metalloprotease -
FTD94_RS14815 17525..18333 - 809 Protein_20 alpha/beta hydrolase -
FTD94_RS14820 18905..19174 + 270 WP_001129937.1 hypothetical protein Antitoxin
FTD94_RS14825 19171..19509 + 339 WP_001022435.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FTD94_RS14830 19684..20367 + 684 WP_000277644.1 CPBP family intramembrane metalloprotease -
FTD94_RS14835 21095..22255 + 1161 WP_015379485.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
FTD94_RS14840 22471..23145 + 675 WP_015379484.1 IS6 family transposase -
FTD94_RS14845 23142..23807 - 666 WP_187107891.1 protein rep -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid blaZ / tet(L) - 1..29537 29537


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 13001.20 Da        Isoelectric Point: 10.1988

>T136023 WP_001022435.1 NZ_CP042651:19171-19509 [Staphylococcus aureus]
MNIKQFDILYIDLNPTRGREKHNVRPCLVINNQMSIDGTNFVWVLPITTRGLRYPTDIQLKTKKGLVSGVIDTVQIRALD
LKARQYNYKDELQDNLKNDILKAIKTYLKPTL

Download         Length: 339 bp

>T136023 NZ_CP042651:19171-19509 [Staphylococcus aureus]
ATGAACATTAAACAATTTGACATACTCTACATTGATTTAAATCCAACTCGTGGACGTGAAAAGCATAACGTAAGGCCCTG
CTTAGTGATAAATAATCAGATGAGTATTGATGGCACTAATTTTGTTTGGGTTTTACCCATAACAACTCGGGGTTTACGTT
ATCCAACAGATATCCAACTTAAAACAAAAAAAGGATTAGTATCTGGTGTGATAGACACTGTTCAAATACGCGCTTTAGAC
CTAAAAGCACGTCAATACAACTATAAAGACGAACTACAGGACAATTTAAAAAATGATATATTAAAAGCGATAAAAACTTA
TCTTAAGCCAACGTTATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10185.65 Da        Isoelectric Point: 10.1641

>AT136023 WP_001129937.1 NZ_CP042651:18905-19174 [Staphylococcus aureus]
MAKSLKDLNKTSERVFKNGNSKAISLSKKTIRLANFDIGDTVEVQKMNGGLFITKKKESIEDRIKNFFQSGGKYTELEVD
WEERVGREI

Download         Length: 270 bp

>AT136023 NZ_CP042651:18905-19174 [Staphylococcus aureus]
ATGGCTAAATCATTAAAAGACTTAAACAAGACTTCGGAACGAGTTTTTAAAAATGGAAACAGTAAAGCAATCAGTTTAAG
TAAAAAAACTATCAGGTTAGCTAATTTTGATATAGGAGATACAGTTGAAGTTCAAAAAATGAATGGTGGTTTGTTCATTA
CTAAAAAAAAGGAGTCTATTGAAGATAGAATTAAAAATTTCTTTCAAAGTGGTGGAAAGTATACAGAATTAGAAGTAGAT
TGGGAAGAAAGAGTTGGCCGAGAAATATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7EWJ
PDB 7EWI

Antitoxin

Source ID Structure
AlphaFold DB L7PH55

References