Detailed information of TA system TA136007

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 887887..888364
• Replicon: chromosome
• Accession: NZ_CP042650
• Organism: Staphylococcus aureus strain X22

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: -
• Locus tag: FTD94_RS04465
• Protein ID: WP_044288767.1
• Coordinates: 887887..888075 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: FTD94_RS04470
• Protein ID: WP_001059690.1
• Coordinates: 888104..888364 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FTD94_RS04435	883930..884400	+	471	WP_000824472.1	hypothetical protein	-
FTD94_RS04440	884741..885427	+	687	WP_147091761.1	thermonuclease family protein	-
FTD94_RS04445	885784..885984	+	201	WP_001059082.1	cold-shock protein	-
FTD94_RS04450	886478..886696	-	219	WP_006189856.1	hypothetical protein	-
FTD94_RS04455	886758..887042	-	285	WP_001004401.1	hypothetical protein	-
FTD94_RS04460	887130..887699	-	570	WP_001106654.1	hypothetical protein	-
FTD94_RS04465	887887..888075	-	189	WP_044288767.1	hypothetical protein	Toxin
FTD94_RS04470	888104..888364	-	261	WP_001059690.1	hypothetical protein	Antitoxin
FTD94_RS04475	888704..888907	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
FTD94_RS04480	888904..889140	-	237	WP_000368687.1	hypothetical protein	-
FTD94_RS04485	889364..889945	+	582	WP_044288768.1	phosphoglycerate mutase family protein	-
FTD94_RS04490	890018..890631	-	614	Protein_849	LysE family transporter	-
FTD94_RS04495	890786..891280	-	495	WP_000569884.1	GNAT family N-acetyltransferase	-
FTD94_RS04505	891679..892101	-	423	WP_044288769.1	organic hydroperoxide resistance protein	-
FTD94_RS04510	892249..892965	+	717	WP_000150020.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (5-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7154.87 Da
• Isoelectric Point: 9.9971

>T136007 WP_044288767.1 NZ_CP042650:c888075-887887 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFIVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T136007 NZ_CP042650:c888075-887887 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCATTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATATACATTTATATTTGGTGTGCTATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT136007 WP_001059690.1 NZ_CP042650:c888364-888104 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT136007 NZ_CP055213:c2564003-2563737 [Klebsiella quasipneumoniae]
ATGCATTCCCCGCAGATATACAGTCCCGTTCAGCTGGCCAATTACCTGAAACTGCTGCGCCAGCAAAATCACTGGACTCA
GGAGGCGCTGGCCAGCCGGATCGGCATTAAACAGGCGACGCTGTCCAATTTTGAAAATCACCCGGACAAAACCACCTTGA
CCACCCTGTTCAAGATCCTCCAGTCGCTGGGGGTGGTGATGACCCTGAACGCCAAACCGGCCGAGACGGCGACGGCCCCC
GATAACACCACGGATCTGGACTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VN56