Detailed information of TA system TA135999

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-RHH
• Location: 2736510..2736972
• Replicon: chromosome
• Accession: NZ_CP042596
• Organism: Granulicella sp. WH15

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: FTO74_RS11375
• Protein ID: WP_162538259.1
• Coordinates: 2736510..2736773 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: FTO74_RS11380
• Protein ID: WP_162538260.1
• Coordinates: 2736760..2736972 (-)
• Length: 71 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FTO74_RS11365	2731810..2732628	+	819	WP_162538257.1	EcsC family protein	-
FTO74_RS11370	2733209..2736496	-	3288	WP_162538258.1	carbamoyl-phosphate synthase large subunit	-
FTO74_RS11375	2736510..2736773	-	264	WP_162538259.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FTO74_RS11380	2736760..2736972	-	213	WP_162538260.1	ribbon-helix-helix protein, CopG family	Antitoxin
FTO74_RS11385	2737004..2738137	-	1134	WP_162538261.1	glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit	-
FTO74_RS11390	2738499..2738825	-	327	WP_162538262.1	Rieske 2Fe-2S domain-containing protein	-
FTO74_RS11395	2738885..2739826	+	942	WP_162538263.1	alpha/beta hydrolase	-
FTO74_RS11400	2739826..2740251	+	426	WP_162538264.1	DoxX family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10327.99 Da
• Isoelectric Point: 9.8466

>T135999 WP_162538259.1 NZ_CP042596:c2736773-2736510 [Granulicella sp. WH15]
VWRTEFTDVAERALLKLDKPVRERILAFFRERVSSSEDPKALAEPLAGEFRGLWRFRVGDYRVICDIRQDVLIVLVLQVG
HRREVYR

Nucleotide

• Length: 264 bp

>T135999 NZ_CP042596:c2736773-2736510 [Granulicella sp. WH15]
GTGTGGCGGACTGAGTTCACCGATGTTGCGGAGCGGGCGCTGCTCAAGTTGGACAAGCCCGTACGGGAACGCATTCTGGC
CTTCTTCCGCGAGCGTGTGAGTTCGTCGGAAGACCCAAAGGCTCTCGCCGAACCGCTTGCAGGGGAGTTTCGCGGACTTT
GGAGATTTCGTGTGGGTGACTATCGCGTCATCTGCGACATACGGCAGGATGTCCTCATCGTCCTGGTACTTCAGGTGGGG
CATCGCAGGGAAGTTTATCGTTAG

Antitoxin

Protein

• Length: 71 a.a.
• Molecular weight: 8070.96 Da
• Isoelectric Point: 4.2925

>AT135999 WP_162538260.1 NZ_CP042596:c2736972-2736760 [Granulicella sp. WH15]
MIEVQLEPELEARLERLAADTHVSKSFFAHEAIQRFVEDREDYLEGIAALSQSKYAISQEEMERRSSVAD

Nucleotide

• Length: 213 bp

>AT135999 NZ_CP042596:c2736972-2736760 [Granulicella sp. WH15]
ATGATCGAAGTCCAGCTTGAACCTGAACTGGAAGCACGGTTGGAGCGTCTCGCGGCTGACACGCATGTCAGCAAGAGCTT
CTTCGCTCACGAGGCGATCCAGCGATTTGTAGAAGATCGCGAAGATTACCTTGAGGGCATTGCCGCTCTCTCTCAATCCA
AGTACGCGATCTCGCAGGAAGAGATGGAGCGGCGATCGAGTGTGGCGGACTGA