Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) rlegTA/AbiEii-AbiEi
Location 2071146..2072658 Replicon chromosome
Accession NZ_CP042596
Organism Granulicella sp. WH15

Toxin (Protein)


Gene name rlegT Uniprot ID -
Locus tag FTO74_RS08685 Protein ID WP_162537785.1
Coordinates 2071146..2072054 (-) Length 303 a.a.

Antitoxin (Protein)


Gene name rlegA Uniprot ID -
Locus tag FTO74_RS08690 Protein ID WP_162537786.1
Coordinates 2072044..2072658 (-) Length 205 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FTO74_RS08660 2066558..2067811 + 1254 WP_162537781.1 tyrosine-type recombinase/integrase -
FTO74_RS08665 2067808..2068779 + 972 WP_162537782.1 tyrosine-type recombinase/integrase -
FTO74_RS08670 2068836..2070140 - 1305 Protein_1704 AAA family ATPase -
FTO74_RS08675 2070490..2070705 - 216 WP_162537783.1 hypothetical protein -
FTO74_RS08680 2070787..2071056 + 270 WP_162537784.1 helix-turn-helix domain-containing protein -
FTO74_RS08685 2071146..2072054 - 909 WP_162537785.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
FTO74_RS08690 2072044..2072658 - 615 WP_162537786.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
FTO74_RS08695 2073021..2073275 + 255 WP_162537787.1 hypothetical protein -
FTO74_RS08700 2073560..2074255 + 696 WP_162537788.1 hypothetical protein -
FTO74_RS08705 2074625..2075410 - 786 WP_162537789.1 UPF0489 family protein -
FTO74_RS08710 2075774..2076907 + 1134 WP_162537790.1 restriction endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(38-257)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(12-54)


Sequences

Toxin        


Download         Length: 303 a.a.        Molecular weight: 33919.87 Da        Isoelectric Point: 5.7107

>T135998 WP_162537785.1 NZ_CP042596:c2072054-2071146 [Granulicella sp. WH15]
MPHETRNVGASVRARLLARSRAESSDYQILLTRYALERLLYRLSVSAHHDRFILKGALLFVTWLPDPFRPTRDLDLLGYG
ASTPEALADTFKAICSTPVPDDGVTFDVEGITAVPIREDVEYGGVRVRTQAIIDGARIPIQVDIGFGDVITPGPVEIDYP
ALLDSPAPHLRAYPVETVIAEKFNAMVTLGIANSRLKDFYDLWLISRTFELDRAVLFAAVQRTFEQRETPIPTDIPTGLT
DQYGEQWGMQWKAFLKREHMNAAPNDLLKLIADLRSFLVPLTIPPRTDSYWISGGPWSIRKN

Download         Length: 909 bp

>T135998 NZ_CP042596:c2072054-2071146 [Granulicella sp. WH15]
ATGCCGCATGAAACTCGTAACGTCGGAGCTTCGGTAAGGGCGAGGCTCCTCGCTCGCTCACGAGCAGAAAGCTCTGACTA
TCAAATCCTTCTGACAAGATACGCACTGGAGAGGCTGCTCTACCGGCTGAGTGTCTCCGCGCACCATGACCGCTTCATCC
TCAAGGGCGCATTGCTCTTTGTGACATGGCTTCCAGATCCATTCCGGCCAACGCGAGACCTTGATCTACTCGGCTATGGA
GCCAGCACCCCGGAGGCACTTGCCGACACCTTCAAAGCTATATGCTCAACTCCTGTTCCTGACGACGGCGTTACTTTCGA
CGTTGAGGGCATAACGGCTGTGCCGATCCGCGAAGACGTTGAGTACGGAGGGGTCCGAGTCCGTACCCAGGCGATCATCG
ACGGCGCACGCATACCCATTCAGGTAGACATCGGCTTTGGGGATGTCATCACGCCGGGGCCCGTCGAGATCGACTACCCC
GCCCTCCTCGACTCGCCAGCACCGCATCTCCGCGCCTATCCGGTTGAAACCGTAATTGCGGAAAAGTTCAACGCTATGGT
GACGCTGGGGATTGCCAATAGTCGGCTTAAAGACTTCTATGACCTTTGGCTGATCTCCCGTACCTTTGAATTGGATCGTG
CTGTTTTGTTCGCTGCTGTGCAACGAACCTTTGAGCAACGGGAAACTCCCATACCAACTGACATACCCACAGGATTGACG
GATCAATATGGGGAGCAGTGGGGTATGCAGTGGAAAGCCTTTCTAAAACGTGAGCACATGAACGCTGCGCCAAATGACCT
GCTTAAGTTGATCGCAGATTTGCGTAGCTTTCTGGTTCCATTGACGATCCCACCCCGTACAGACTCCTACTGGATCTCTG
GCGGCCCTTGGTCAATCCGCAAGAATTAG

Antitoxin


Download         Length: 205 a.a.        Molecular weight: 23519.60 Da        Isoelectric Point: 9.3824

>AT135998 WP_162537786.1 NZ_CP042596:c2072658-2072044 [Granulicella sp. WH15]
MLATQRTRALDLLKARGMLRLRDFIAENIEPETLARLVREEQVIRPARGLYQLPDTEIEAAYMLAEASVLVPKGIVCLIS
ALQFHELTLQMPSAVWMAIERTAWRPMISYPPIRFVRFSGWAMTEGVEMYLIQSREVPITNPARTIVDCFRYRNKIGIDV
AIEGLREGIRHRKCTPDQLWQYAKKARVWTVMRPYVETVVSDAA

Download         Length: 615 bp

>AT135998 NZ_CP042596:c2072658-2072044 [Granulicella sp. WH15]
ATGCTCGCCACTCAACGAACCCGTGCTCTCGATCTTCTAAAGGCCAGAGGGATGCTTCGTCTTCGGGACTTTATTGCTGA
AAACATTGAGCCGGAGACTCTGGCGCGACTGGTCAGAGAGGAGCAAGTCATTCGCCCCGCACGTGGGCTTTACCAGCTTC
CAGATACTGAGATCGAAGCAGCTTACATGCTTGCCGAGGCTTCTGTGCTCGTGCCCAAAGGAATTGTCTGCCTCATCTCA
GCTCTCCAATTTCATGAACTGACGCTCCAGATGCCTTCCGCCGTGTGGATGGCAATCGAACGTACCGCATGGCGGCCTAT
GATCAGCTATCCGCCCATTCGCTTTGTCCGGTTTAGCGGATGGGCTATGACCGAGGGAGTAGAGATGTATCTCATTCAAT
CCCGCGAAGTCCCGATCACAAACCCTGCGCGAACCATCGTGGACTGCTTTCGGTACCGCAACAAGATTGGCATTGACGTA
GCCATAGAAGGACTGCGCGAAGGTATTCGACATCGCAAATGTACGCCGGATCAGCTTTGGCAATATGCGAAGAAAGCGCG
GGTCTGGACGGTAATGCGTCCCTATGTCGAAACGGTGGTATCCGATGCCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References