135952

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1287702..1288327 Replicon chromosome
Accession NZ_CP042585
Organism Escherichia coli strain LD91-1

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag FQR64_RS06720 Protein ID WP_000911329.1
Coordinates 1287929..1288327 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag FQR64_RS06715 Protein ID WP_000450524.1
Coordinates 1287702..1287929 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FQR64_RS06690 1283504..1283974 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
FQR64_RS06695 1283974..1284546 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
FQR64_RS06700 1284692..1285570 + 879 WP_001311023.1 4-hydroxy-tetrahydrodipicolinate synthase -
FQR64_RS06705 1285587..1286621 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
FQR64_RS06710 1286834..1287547 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
FQR64_RS06715 1287702..1287929 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
FQR64_RS06720 1287929..1288327 + 399 WP_000911329.1 tRNA(fMet)-specific endonuclease VapC Toxin
FQR64_RS06725 1288474..1289337 + 864 WP_001267498.1 neutral zinc metallopeptidase -
FQR64_RS06730 1289352..1291367 + 2016 WP_000829294.1 tRNA cytosine(34) acetyltransferase TmcA -
FQR64_RS06735 1291441..1292139 + 699 WP_000679823.1 esterase -
FQR64_RS06740 1292249..1292449 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T135952 WP_000911329.1 NZ_CP042585:1287929-1288327 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T135952 NZ_CP042585:1287929-1288327 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACT
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGATTGGAGCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT135952 WP_000450524.1 NZ_CP042585:1287702-1287929 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT135952 NZ_CP042585:1287702-1287929 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAGGATGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References