Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3939958..3940615 Replicon chromosome
Accession NZ_CP042578
Organism Enterobacter kobei strain C16

Toxin (Protein)


Gene name cptA Uniprot ID A0A2W0G6Z0
Locus tag FR825_RS19420 Protein ID WP_014885136.1
Coordinates 3939958..3940368 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag FR825_RS19425 Protein ID WP_010435322.1
Coordinates 3940349..3940615 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FR825_RS19400 3935952..3937685 - 1734 WP_023331239.1 single-stranded-DNA-specific exonuclease RecJ -
FR825_RS19405 3937691..3938404 - 714 WP_014885133.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FR825_RS19410 3938433..3939329 - 897 WP_023337727.1 site-specific tyrosine recombinase XerD -
FR825_RS19415 3939431..3939952 + 522 WP_014885135.1 flavodoxin FldB -
FR825_RS19420 3939958..3940368 - 411 WP_014885136.1 protein YgfX Toxin
FR825_RS19425 3940349..3940615 - 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
FR825_RS19430 3940910..3941890 + 981 WP_023337728.1 tRNA-modifying protein YgfZ -
FR825_RS19435 3941975..3942634 - 660 WP_023331242.1 hemolysin III family protein -
FR825_RS19440 3942900..3943631 + 732 WP_032645400.1 MurR/RpiR family transcriptional regulator -
FR825_RS19445 3943748..3945181 + 1434 WP_038421024.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16135.04 Da        Isoelectric Point: 10.7510

>T135944 WP_014885136.1 NZ_CP042578:c3940368-3939958 [Enterobacter kobei]
VVLWQSDLRVSWRSQWMSLMLHGLVAAIVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNSGMMLRLRNVDGGRCQHLWLAADSMDASEWRDLRRMLLQQPTQE

Download         Length: 411 bp

>T135944 NZ_CP042578:c3940368-3939958 [Enterobacter kobei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCGTTAATGCTCCACGGCCTGGTTGCGGC
CATCGTGTTACTCATGCCATGGCCCCTGAGCTATACGCCGCTGTGGCTGCTGTTACTTTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAATGCTCGTCAGGGTGAGATCAAGTTACTGATGGATTCCCGCCTGCGCTGGCAGGGAAAA
GAGTGGGATATTCTGGGCATGCCATGGATGCTCAACTCCGGCATGATGTTACGGTTACGCAATGTGGACGGCGGGCGTTG
CCAGCACCTGTGGCTGGCGGCTGACAGTATGGATGCCTCAGAATGGCGAGATCTGCGCCGGATGTTGTTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT135944 WP_010435322.1 NZ_CP042578:c3940615-3940349 [Enterobacter kobei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT135944 NZ_CP042578:c3940615-3940349 [Enterobacter kobei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCATGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGGCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCAGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W0G6Z0

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References