Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 1537621..1538534 Replicon chromosome
Accession NZ_CP042578
Organism Enterobacter kobei strain C16

Toxin (Protein)


Gene name - Uniprot ID A0A2J0PLX5
Locus tag FR825_RS07365 Protein ID WP_023337016.1
Coordinates 1537621..1538094 (-) Length 158 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A2J0PMR8
Locus tag FR825_RS07370 Protein ID WP_023337017.1
Coordinates 1538091..1538534 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FR825_RS07345 1534048..1535091 + 1044 WP_088555711.1 type I-F CRISPR-associated protein Csy1 -
FR825_RS07350 1535088..1536023 + 936 WP_047028481.1 type I-F CRISPR-associated protein Csy2 -
FR825_RS07355 1536037..1537035 + 999 WP_038421207.1 type I-F CRISPR-associated protein Csy3 -
FR825_RS07360 1537045..1537599 + 555 WP_023337015.1 type I-F CRISPR-associated endoribonuclease Cas6/Csy4 -
FR825_RS07365 1537621..1538094 - 474 WP_023337016.1 RES domain-containing protein Toxin
FR825_RS07370 1538091..1538534 - 444 WP_023337017.1 DUF2384 domain-containing protein Antitoxin
FR825_RS07375 1539751..1539969 - 219 WP_002211347.1 translation initiation factor IF-1 -
FR825_RS07380 1540254..1540958 - 705 WP_023337019.1 leucyl/phenylalanyl-tRNA--protein transferase -
FR825_RS07385 1541004..1542725 - 1722 WP_014883200.1 cysteine/glutathione ABC transporter ATP-binding protein/permease CydC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre

(15-147)


Sequences

Toxin        


Download         Length: 158 a.a.        Molecular weight: 17570.82 Da        Isoelectric Point: 5.0700

>T135935 WP_023337016.1 NZ_CP042578:c1538094-1537621 [Enterobacter kobei]
MIFYRLVTGRYASEAWSGSGANQYGGRWNHKGHPAVYVSTSISLASLEILVHVRKDTVLNQYQLFSIDIPDDQIDYLDKA
WLPEDWQENPAPVSTMDLGTGWLQANSALALILPSCIIPYENNAILNPLHPSFHTALNSVQQLPFNFDTRLAEKTAP

Download         Length: 474 bp

>T135935 NZ_CP055194:858566-858973 [Shigella flexneri]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16349.68 Da        Isoelectric Point: 7.2062

>AT135935 WP_023337017.1 NZ_CP042578:c1538534-1538091 [Enterobacter kobei]
MRTWIPAQKPADNALWRYAGLPANRGMRLIEFLNQGLPVSVLDNIHEWTAMSKADILRVTGINERNVARRKSAGRTLTPD
ESERVARFVRVLDAAVDYFGSKEEAWNWLQAPVRGLGNVAPVDLIATETGALEVTDLIGRLEHGVFA

Download         Length: 444 bp

>AT135935 NZ_CP042578:c1538534-1538091 [Enterobacter kobei]
ATGAGAACATGGATCCCCGCGCAGAAACCTGCTGATAACGCGCTTTGGCGGTACGCCGGTTTACCTGCAAACAGAGGTAT
GCGGCTGATTGAATTTCTCAATCAGGGATTACCCGTCAGCGTCCTCGACAATATCCATGAGTGGACGGCGATGTCGAAAG
CGGACATTTTGCGCGTCACCGGAATTAATGAACGTAACGTGGCCCGGCGCAAAAGCGCGGGACGGACGCTGACGCCGGAT
GAAAGCGAACGCGTGGCCCGTTTCGTTCGGGTGCTGGATGCTGCTGTCGACTATTTTGGCAGTAAAGAAGAGGCATGGAA
CTGGCTGCAGGCACCGGTGCGCGGGCTAGGGAATGTTGCCCCTGTCGACCTGATCGCGACCGAAACCGGTGCACTGGAAG
TCACCGACTTGATTGGTCGACTCGAACATGGTGTGTTCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J0PLX5

Antitoxin

Source ID Structure
AlphaFold DB A0A2J0PMR8

References