Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 476070..476586 Replicon chromosome
Accession NZ_CP042578
Organism Enterobacter kobei strain C16

Toxin (Protein)


Gene name relE Uniprot ID A0A2J0PPK2
Locus tag FR825_RS02315 Protein ID WP_014882291.1
Coordinates 476302..476586 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V3EXX3
Locus tag FR825_RS02310 Protein ID WP_008501400.1
Coordinates 476070..476312 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FR825_RS02295 472165..472908 + 744 WP_023331886.1 KDGP aldolase family protein -
FR825_RS02300 472926..474062 + 1137 WP_014882289.1 lactonase family protein -
FR825_RS02305 474082..475992 + 1911 WP_014882290.1 BglG family transcription antiterminator -
FR825_RS02310 476070..476312 + 243 WP_008501400.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FR825_RS02315 476302..476586 + 285 WP_014882291.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FR825_RS02320 476590..477054 - 465 WP_014882292.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
FR825_RS02325 477196..479334 - 2139 WP_038421312.1 anaerobic ribonucleoside-triphosphate reductase -
FR825_RS02330 479704..480276 - 573 WP_014882294.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10894.69 Da        Isoelectric Point: 10.1988

>T135932 WP_014882291.1 NZ_CP042578:476302-476586 [Enterobacter kobei]
MTYELVFDPRALKEWSKLGDTVKNQFKKKLADVLVNPRVESARLHGLPDCYKIKLRSQGYRLVYQVQDDVVTVFVIAVGK
REKSAVYHDANKRL

Download         Length: 285 bp

>T135932 NZ_CP042578:476302-476586 [Enterobacter kobei]
ATGACTTATGAACTGGTATTTGACCCGAGGGCGTTAAAGGAGTGGAGCAAGCTGGGCGATACCGTAAAAAACCAATTTAA
GAAGAAGCTTGCGGACGTGTTGGTGAATCCCAGGGTTGAATCGGCTCGCCTGCATGGCCTGCCTGATTGCTACAAGATAA
AACTGAGATCCCAGGGTTATCGTTTGGTCTATCAGGTTCAGGATGACGTTGTAACGGTATTTGTTATTGCTGTCGGTAAG
AGAGAGAAGTCAGCCGTTTATCATGACGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8972.37 Da        Isoelectric Point: 5.0651

>AT135932 WP_008501400.1 NZ_CP042578:476070-476312 [Enterobacter kobei]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTISDSEDALIQTVRERLANPQKGIKVSLDDL

Download         Length: 243 bp

>AT135932 NZ_CP042578:476070-476312 [Enterobacter kobei]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTCAATATCACGCC
AACGGAAGCTGTGCGTTTACTGTTTCAGTATGTCGCGGAAACGGGACGCATGCCGGTGAAAACGGTCACCATTAGCGACA
GTGAAGATGCACTGATACAGACAGTCCGGGAGCGACTGGCTAATCCGCAAAAGGGAATCAAGGTCAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J0PPK2

Antitoxin

Source ID Structure
AlphaFold DB V3EXX3

References