Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1(toxin) |
Location | 4757328..4757944 | Replicon | chromosome |
Accession | NZ_CP042571 | ||
Organism | Enterobacter hormaechei strain E5 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | - |
Locus tag | FR760_RS23070 | Protein ID | WP_080346796.1 |
Coordinates | 4757328..4757699 (-) | Length | 124 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | A0A9E7BIL4 |
Locus tag | FR760_RS23075 | Protein ID | WP_023298920.1 |
Coordinates | 4757702..4757944 (-) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FR760_RS23055 | 4754828..4755730 | + | 903 | WP_003861960.1 | formate dehydrogenase subunit beta | - |
FR760_RS23060 | 4755727..4756362 | + | 636 | WP_006808711.1 | formate dehydrogenase cytochrome b556 subunit | - |
FR760_RS23065 | 4756359..4757288 | + | 930 | WP_023305104.1 | formate dehydrogenase accessory protein FdhE | - |
FR760_RS23070 | 4757328..4757699 | - | 372 | WP_080346796.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
FR760_RS23075 | 4757702..4757944 | - | 243 | WP_023298920.1 | ribbon-helix-helix protein, CopG family | Antitoxin |
FR760_RS23080 | 4758144..4759064 | + | 921 | WP_023305106.1 | alpha/beta hydrolase | - |
FR760_RS23085 | 4759073..4760014 | - | 942 | WP_023305107.1 | fatty acid biosynthesis protein FabY | - |
FR760_RS23090 | 4760059..4760496 | - | 438 | WP_023305108.1 | D-tyrosyl-tRNA(Tyr) deacylase | - |
FR760_RS23095 | 4760493..4761374 | - | 882 | WP_023298923.1 | virulence factor BrkB family protein | - |
FR760_RS23100 | 4761368..4761967 | - | 600 | WP_023305109.1 | glucose-1-phosphatase | - |
FR760_RS23105 | 4762086..4762886 | - | 801 | WP_023305110.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 124 a.a. Molecular weight: 13668.73 Da Isoelectric Point: 6.2151
>T135928 WP_080346796.1 NZ_CP042571:c4757699-4757328 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNHVEAADAIDRTASHRAISLITWMEVMVGARRHGQEAKTAAVMEAFEIIDITREIAERSVLLR
EQHGMKLPDAIILATAQSRSCPLISRNTKDFSGIAGVVSPYHL
MEHMAVFDTNILIDLFNNHVEAADAIDRTASHRAISLITWMEVMVGARRHGQEAKTAAVMEAFEIIDITREIAERSVLLR
EQHGMKLPDAIILATAQSRSCPLISRNTKDFSGIAGVVSPYHL
Download Length: 372 bp
>T135928 NZ_CP042571:c4757699-4757328 [Enterobacter hormaechei]
ATGGAGCACATGGCTGTGTTTGACACCAATATCCTCATCGATCTTTTTAATAACCACGTTGAGGCTGCGGATGCGATCGA
TCGCACAGCTTCGCATCGTGCCATTAGCCTCATCACATGGATGGAAGTAATGGTGGGCGCTCGCAGGCACGGTCAAGAAG
CAAAAACGGCAGCCGTGATGGAGGCCTTTGAAATTATTGATATAACAAGGGAAATTGCTGAAAGAAGCGTATTACTTCGC
GAACAGCACGGGATGAAGCTTCCTGACGCCATTATTCTGGCTACTGCTCAGAGCAGAAGCTGTCCGTTAATTTCGCGCAA
TACGAAAGACTTTTCGGGTATTGCTGGGGTCGTTTCACCTTACCACCTGTAG
ATGGAGCACATGGCTGTGTTTGACACCAATATCCTCATCGATCTTTTTAATAACCACGTTGAGGCTGCGGATGCGATCGA
TCGCACAGCTTCGCATCGTGCCATTAGCCTCATCACATGGATGGAAGTAATGGTGGGCGCTCGCAGGCACGGTCAAGAAG
CAAAAACGGCAGCCGTGATGGAGGCCTTTGAAATTATTGATATAACAAGGGAAATTGCTGAAAGAAGCGTATTACTTCGC
GAACAGCACGGGATGAAGCTTCCTGACGCCATTATTCTGGCTACTGCTCAGAGCAGAAGCTGTCCGTTAATTTCGCGCAA
TACGAAAGACTTTTCGGGTATTGCTGGGGTCGTTTCACCTTACCACCTGTAG
Antitoxin
Download Length: 81 a.a. Molecular weight: 9467.74 Da Isoelectric Point: 4.3775
>AT135928 WP_023298920.1 NZ_CP042571:c4757944-4757702 [Enterobacter hormaechei]
MSLLADLTMGRILIDLSDDVIQRLDNLKQLRNRPRAELLREAIELYLDQQNSSVIREALGLWGNQQEDGLEYERKLREEW
MSLLADLTMGRILIDLSDDVIQRLDNLKQLRNRPRAELLREAIELYLDQQNSSVIREALGLWGNQQEDGLEYERKLREEW
Download Length: 243 bp
>AT135928 NZ_CP055186:c4652991-4652725 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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