Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4757328..4757944 Replicon chromosome
Accession NZ_CP042571
Organism Enterobacter hormaechei strain E5

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FR760_RS23070 Protein ID WP_080346796.1
Coordinates 4757328..4757699 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A9E7BIL4
Locus tag FR760_RS23075 Protein ID WP_023298920.1
Coordinates 4757702..4757944 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FR760_RS23055 4754828..4755730 + 903 WP_003861960.1 formate dehydrogenase subunit beta -
FR760_RS23060 4755727..4756362 + 636 WP_006808711.1 formate dehydrogenase cytochrome b556 subunit -
FR760_RS23065 4756359..4757288 + 930 WP_023305104.1 formate dehydrogenase accessory protein FdhE -
FR760_RS23070 4757328..4757699 - 372 WP_080346796.1 type II toxin-antitoxin system VapC family toxin Toxin
FR760_RS23075 4757702..4757944 - 243 WP_023298920.1 ribbon-helix-helix protein, CopG family Antitoxin
FR760_RS23080 4758144..4759064 + 921 WP_023305106.1 alpha/beta hydrolase -
FR760_RS23085 4759073..4760014 - 942 WP_023305107.1 fatty acid biosynthesis protein FabY -
FR760_RS23090 4760059..4760496 - 438 WP_023305108.1 D-tyrosyl-tRNA(Tyr) deacylase -
FR760_RS23095 4760493..4761374 - 882 WP_023298923.1 virulence factor BrkB family protein -
FR760_RS23100 4761368..4761967 - 600 WP_023305109.1 glucose-1-phosphatase -
FR760_RS23105 4762086..4762886 - 801 WP_023305110.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-114)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13668.73 Da        Isoelectric Point: 6.2151

>T135928 WP_080346796.1 NZ_CP042571:c4757699-4757328 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNHVEAADAIDRTASHRAISLITWMEVMVGARRHGQEAKTAAVMEAFEIIDITREIAERSVLLR
EQHGMKLPDAIILATAQSRSCPLISRNTKDFSGIAGVVSPYHL

Download         Length: 372 bp

>T135928 NZ_CP042571:c4757699-4757328 [Enterobacter hormaechei]
ATGGAGCACATGGCTGTGTTTGACACCAATATCCTCATCGATCTTTTTAATAACCACGTTGAGGCTGCGGATGCGATCGA
TCGCACAGCTTCGCATCGTGCCATTAGCCTCATCACATGGATGGAAGTAATGGTGGGCGCTCGCAGGCACGGTCAAGAAG
CAAAAACGGCAGCCGTGATGGAGGCCTTTGAAATTATTGATATAACAAGGGAAATTGCTGAAAGAAGCGTATTACTTCGC
GAACAGCACGGGATGAAGCTTCCTGACGCCATTATTCTGGCTACTGCTCAGAGCAGAAGCTGTCCGTTAATTTCGCGCAA
TACGAAAGACTTTTCGGGTATTGCTGGGGTCGTTTCACCTTACCACCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9467.74 Da        Isoelectric Point: 4.3775

>AT135928 WP_023298920.1 NZ_CP042571:c4757944-4757702 [Enterobacter hormaechei]
MSLLADLTMGRILIDLSDDVIQRLDNLKQLRNRPRAELLREAIELYLDQQNSSVIREALGLWGNQQEDGLEYERKLREEW

Download         Length: 243 bp

>AT135928 NZ_CP055186:c4652991-4652725 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References