Detailed information of TA system TA135918

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 2401086..2401825
• Replicon: chromosome
• Accession: NZ_CP042571
• Organism: Enterobacter hormaechei strain E5

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: FR760_RS11800
• Protein ID: WP_032624244.1
• Coordinates: 2401086..2401571 (-)
• Length: 162 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: A0A837FCR9
• Locus tag: FR760_RS11805
• Protein ID: WP_003857131.1
• Coordinates: 2401559..2401825 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FR760_RS11765	2396382..2397890	-	1509	WP_047358972.1	group II intron reverse transcriptase/maturase	-
FR760_RS11775	2398563..2399242	-	680	Protein_2274	IS3 family transposase	-
FR760_RS11780	2399308..2399421	-	114	WP_121909848.1	Hok/Gef family protein	-
FR760_RS11785	2399773..2400054	+	282	Protein_2276	DUF4225 domain-containing protein	-
FR760_RS11790	2400029..2400358	-	330	WP_023306210.1	hypothetical protein	-
FR760_RS11795	2400491..2401060	+	570	WP_023306211.1	hypothetical protein	-
FR760_RS11800	2401086..2401571	-	486	WP_032624244.1	GNAT family N-acetyltransferase	Toxin
FR760_RS11805	2401559..2401825	-	267	WP_003857131.1	DUF1778 domain-containing protein	Antitoxin
FR760_RS11810	2401889..2402818	-	930	WP_151884370.1	LysR family transcriptional regulator	-
FR760_RS11815	2402948..2404336	+	1389	WP_023306214.1	MFS transporter	-
FR760_RS11820	2404315..2404872	-	558	WP_023300131.1	OmpH family outer membrane protein	-
FR760_RS11825	2404993..2406129	-	1137	WP_032676232.1	type 1 fimbrial protein	-
FR760_RS11830	2406153..2406677	-	525	WP_087878309.1	fimbrial protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (58-151)

Antitoxin

• Vibrio phage ICP1, Orf50 (6-82)

Sequences

Toxin

Protein

• Length: 162 a.a.
• Molecular weight: 17531.27 Da
• Isoelectric Point: 10.1788

>T135918 WP_032624244.1 NZ_CP042571:c2401571-2401086 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDVSIRGNGLGADLLQDAVLRCYRVAENIGVRAIMVHALTEKAKAFYIHHGFKASQTQERTLFLRLP
Q

Nucleotide

• Length: 486 bp

>T135918 NZ_CP042571:c2401571-2401086 [Enterobacter hormaechei]
GTGGGACGTGTAACCGCCCCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGTGGAGAGGCCGTACTTGA
CGAATGGTTAAAACAAAGAGGTCTGAAAAACCAGGCGCTTGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACAA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGGAAGCGACAGGTAATTTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATTCTTGCCCGTCTGGCTGTCGATGTCTCAATACGCGGAAATGGGTTGGGAGCCGATTT
ACTCCAGGATGCGGTTTTACGCTGTTATCGGGTAGCAGAGAATATTGGGGTGCGGGCGATCATGGTTCATGCACTCACTG
AAAAAGCCAAAGCGTTTTATATCCACCATGGTTTTAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCAGGCTTCCT
CAGTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10090.50 Da
• Isoelectric Point: 4.3837

>AT135918 WP_003857131.1 NZ_CP042571:c2401825-2401559 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Nucleotide

• Length: 267 bp

>AT135918 NZ_CP042571:c2401825-2401559 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTTAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTACA
TAAATCACGTACTGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAAAATGTGATCCTCGATCGGCGTGTATTCAATT
TTAACGATGAACAGTATGCAGAGTTCATTGATATGCTTGATGCCCCGGTCGCCGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A837FCR9