Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1205322..1205943 Replicon chromosome
Accession NZ_CP042571
Organism Enterobacter hormaechei strain E5

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag FR760_RS05945 Protein ID WP_015571250.1
Coordinates 1205322..1205540 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag FR760_RS05950 Protein ID WP_006809850.1
Coordinates 1205569..1205943 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FR760_RS05915 1201334..1201594 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
FR760_RS05920 1201597..1201737 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
FR760_RS05925 1201734..1202444 - 711 WP_023305593.1 GNAT family N-acetyltransferase -
FR760_RS05930 1202547..1204007 + 1461 WP_023305594.1 PLP-dependent aminotransferase family protein -
FR760_RS05935 1203979..1204446 - 468 WP_023305595.1 hypothetical protein -
FR760_RS05940 1204563..1205114 - 552 WP_023305596.1 maltose O-acetyltransferase -
FR760_RS05945 1205322..1205540 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
FR760_RS05950 1205569..1205943 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
FR760_RS05955 1206453..1209599 - 3147 WP_023299464.1 multidrug efflux RND transporter permease subunit -
FR760_RS05960 1209622..1210815 - 1194 WP_022647272.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T135917 WP_015571250.1 NZ_CP042571:c1205540-1205322 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T135917 NZ_CP042571:c1205540-1205322 [Enterobacter hormaechei]
ATGTCTGATAAACCATTAACTAAAGTCGATTATTTGATGCGCCTGCGACGCTGTCAGTCAATTGACACGCTCGAACGTGT
TATTGAGAAAAATAAATACGAGCTGTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTTGCTGAAC
TGACCATGAATAAACTCTATGACAAGATCCCCTCTTCGGTATGGAAATTTGTTCGTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT135917 WP_006809850.1 NZ_CP042571:c1205943-1205569 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT135917 NZ_CP042571:c1205943-1205569 [Enterobacter hormaechei]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGAAGAAAGTAACCATGGCTGGGTGAACGATCCAACGTCTGCTATCAATTTACAGCTTAATGAGCTGATCGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGTCT
ATTTCGCTGCTTCACGAATGTCAGCAGAGCTAATCCGGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References