Detailed information of TA system TA135911

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 4631453..4632069
• Replicon: chromosome
• Accession: NZ_CP042566
• Organism: Enterobacter hormaechei strain C44

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FR837_RS22210
• Protein ID: WP_015569913.1
• Coordinates: 4631453..4631824 (-)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A6G4MTK3
• Locus tag: FR837_RS22215
• Protein ID: WP_015569912.1
• Coordinates: 4631827..4632069 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FR837_RS22195	4628953..4629855	+	903	WP_014072386.1	formate dehydrogenase subunit beta	-
FR837_RS22200	4629852..4630487	+	636	WP_015569914.1	formate dehydrogenase cytochrome b556 subunit	-
FR837_RS22205	4630484..4631413	+	930	WP_003861956.1	formate dehydrogenase accessory protein FdhE	-
FR837_RS22210	4631453..4631824	-	372	WP_015569913.1	PIN domain-containing protein	Toxin
FR837_RS22215	4631827..4632069	-	243	WP_015569912.1	ribbon-helix-helix domain-containing protein	Antitoxin
FR837_RS22220	4632268..4633188	+	921	WP_015569911.1	alpha/beta hydrolase	-
FR837_RS22225	4633197..4634138	-	942	WP_015569910.1	fatty acid biosynthesis protein FabY	-
FR837_RS22230	4634183..4634620	-	438	WP_015569909.1	D-tyrosyl-tRNA(Tyr) deacylase	-
FR837_RS22235	4634617..4635498	-	882	WP_003861949.1	virulence factor BrkB family protein	-
FR837_RS22240	4635492..4636091	-	600	WP_017694048.1	glucose-1-phosphatase	-
FR837_RS22245	4636210..4637010	-	801	WP_003861944.1	DeoR/GlpR family DNA-binding transcription regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-115)

Antitoxin

• Ribbon-helix-helix protein, CopG (12-49)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13767.90 Da
• Isoelectric Point: 6.4882

>T135911 WP_015569913.1 NZ_CP042566:c4631824-4631453 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNRIEAADAIEHTASHRAISLITWMEVMVSARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQV

Nucleotide

• Length: 372 bp

>T135911 NZ_CP042566:c4631824-4631453 [Enterobacter hormaechei]
ATGGAGCACATGGCAGTGTTTGATACCAATATTCTCATTGATCTCTTCAACAACCGTATTGAAGCTGCGGATGCGATTGA
GCATACCGCGTCGCATCGTGCCATCAGCTTAATTACCTGGATGGAAGTAATGGTGAGCGCTCGCAGGCATGGTCATGAAG
CGAAAACGGCAGCCGTTATGGGCGCTTTTGAAATTATTGATGTGTCTCGGGATATTGCGGAAAGAAGCGTTTTACTACGT
GAGAAGCATGGAATGAAACTGCCTGATGCTATCATTCTGGCCACAGCGCAGAGCAGAAAATGTCCGTTGATTTCTCGCAA
CACGAAAGATTTTGCGGGTATTGACGAGGTCCTTACGCCTTACCAGGTGTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9440.72 Da
• Isoelectric Point: 4.4076

>AT135911 WP_015569912.1 NZ_CP042566:c4632069-4631827 [Enterobacter hormaechei]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Nucleotide

• Length: 243 bp

>AT135911 NZ_CP042566:c4632069-4631827 [Enterobacter hormaechei]
ATGAGCGTTTTGGCGGAACTTGATATGGGCAGAATACTTATCGATTTGTCTGATGACGTGATTCAACGTTTGGATAATCT
CAAGCAATTGCGAAATCAACCACGTGCTGAACTGCTTCGGGAAGCGATAGAGCTGTATCTCGACCAGCAGAGTTCTTCTG
TTATCCGAAATGCGCTTGGTCTGTGGGGAGACAGAAAAGAGGACGGGCTTGAGTATGAACGCAAGCTGCGTGAGGAGTGG
TAA

Structures

Antitoxin

• AlphaFold DB: A0A6G4MTK3