Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 2653358..2654437 Replicon chromosome
Accession NZ_CP042566
Organism Enterobacter hormaechei strain C44

Toxin (Protein)


Gene name panT Uniprot ID A0A7G3F048
Locus tag FR837_RS12725 Protein ID WP_039270560.1
Coordinates 2653358..2653945 (-) Length 196 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A7G3ETZ9
Locus tag FR837_RS12730 Protein ID WP_039270559.1
Coordinates 2653967..2654437 (-) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FR837_RS12700 2649267..2650730 + 1464 WP_017693253.1 16S rRNA (cytosine(1407)-C(5))-methyltransferase RsmF -
FR837_RS12705 2650838..2651077 + 240 WP_003859885.1 YebV family protein -
FR837_RS12710 2651112..2651756 - 645 WP_015570293.1 protein-serine/threonine phosphatase -
FR837_RS12715 2651924..2652904 + 981 WP_039270562.1 VirK/YbjX family protein -
FR837_RS12720 2652950..2653129 + 180 WP_039270561.1 hypothetical protein -
FR837_RS12725 2653358..2653945 - 588 WP_039270560.1 hypothetical protein Toxin
FR837_RS12730 2653967..2654437 - 471 WP_039270559.1 SocA family protein Antitoxin
FR837_RS12735 2654759..2655076 - 318 WP_039270558.1 hypothetical protein -
FR837_RS12740 2655344..2655604 - 261 WP_039270557.1 hypothetical protein -
FR837_RS12745 2655588..2655872 - 285 WP_039270555.1 phage holin family protein -
FR837_RS12750 2656012..2656209 - 198 WP_127850788.1 hypothetical protein -
FR837_RS12755 2656239..2656673 - 435 WP_039270553.1 hypothetical protein -
FR837_RS12765 2658685..2659200 - 516 WP_039270551.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2636363..2666415 30052


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(27-122)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21051.73 Da        Isoelectric Point: 4.9672

>T135900 WP_039270560.1 NZ_CP042566:c2653945-2653358 [Enterobacter hormaechei]
VSIVEDIFKVIGAASGLEQIRTDSDPTKTSQSKNSNPKTESSKGSGSAEEKGKSETSDGAAPSEPDDKAEREAEEFGSNT
GALHEFMQQNRMDSLQAQLDMLKSGVRDKIADANGKEIDNVLRKKMASFTFSFMVCWCLFVGTMFVSYLIAHEGKPPPET
MIALLGTSTLSIVGLVGFVVSGLFKSRKEGSEKEK

Download         Length: 588 bp

>T135900 NZ_CP055181:c2814393-2814016 [Shigella flexneri]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCCCGCCGGGCGACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17314.82 Da        Isoelectric Point: 8.0154

>AT135900 WP_039270559.1 NZ_CP042566:c2654437-2653967 [Enterobacter hormaechei]
MYSPVQVANRFVMLGNQHMNPLTHMQLQKLTYIAHGYYLALTGRPLINEPVSAWKYGPVIPGMYDAFKDFGNRPVTNPVM
SPYGMGVFDPQAESVIGAVFQYYGNKGGIELSTLTHLPGTPWSRAYNGFSSTIIPDGVIKSYYDDLVANRQTCQGL

Download         Length: 471 bp

>AT135900 NZ_CP042566:c2654437-2653967 [Enterobacter hormaechei]
ATGTACAGTCCGGTACAGGTAGCCAATCGATTTGTTATGTTGGGCAATCAACATATGAATCCTCTGACTCATATGCAACT
TCAAAAGTTGACATACATTGCCCATGGTTATTATCTGGCTTTAACAGGGCGTCCGTTAATCAATGAACCTGTTTCTGCTT
GGAAGTATGGCCCTGTAATTCCAGGAATGTATGACGCATTTAAAGACTTTGGAAACAGGCCAGTTACAAACCCTGTCATG
AGTCCTTACGGAATGGGAGTATTCGACCCGCAAGCGGAAAGTGTCATTGGTGCAGTATTCCAATATTACGGCAACAAGGG
CGGGATTGAATTGTCCACTTTAACCCATTTACCTGGCACTCCATGGTCCAGAGCATACAACGGGTTTAGTTCTACGATTA
TACCTGACGGTGTAATCAAGTCTTACTACGATGATCTTGTTGCCAATCGGCAAACTTGTCAAGGCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G3F048

Antitoxin

Source ID Structure
AlphaFold DB A0A7G3ETZ9

References