Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2274708..2275447 Replicon chromosome
Accession NZ_CP042566
Organism Enterobacter hormaechei strain C44

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag FR837_RS10950 Protein ID WP_003857133.1
Coordinates 2274708..2275193 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag FR837_RS10955 Protein ID WP_003857131.1
Coordinates 2275181..2275447 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FR837_RS10925 2270252..2271010 - 759 WP_017693420.1 trans-aconitate 2-methyltransferase -
FR837_RS10930 2271095..2271679 - 585 WP_039270753.1 NUDIX domain-containing protein -
FR837_RS10935 2271766..2272524 + 759 WP_015570520.1 DeoR/GlpR family DNA-binding transcription regulator -
FR837_RS10940 2272629..2273921 + 1293 WP_032648327.1 glycoside hydrolase -
FR837_RS10945 2273921..2274535 + 615 WP_080338042.1 NUDIX hydrolase -
FR837_RS10950 2274708..2275193 - 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
FR837_RS10955 2275181..2275447 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
FR837_RS10960 2275511..2276440 - 930 WP_039270752.1 LysR family transcriptional regulator -
FR837_RS10965 2276570..2277952 + 1383 WP_039270751.1 MFS transporter -
FR837_RS10970 2277974..2278969 - 996 WP_015570513.1 DUF2891 domain-containing protein -
FR837_RS10975 2278979..2279965 - 987 WP_023296632.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2261344..2275447 14103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T135899 WP_003857133.1 NZ_CP042566:c2275193-2274708 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T135899 NZ_CP042566:c2275193-2274708 [Enterobacter hormaechei]
GTGGGACGTGTAACAGCACCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGTGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGGAGCGTTAACCATACGCAAGCGACAGGTAATCTGCGGCGTAACATG
CCGGATCCCATACCCGTGATTATACTTGCCCGTCTGGCTGTGGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGGGTAGCTGAGAATATCGGGGTGCGAGCGATCATGGTTCATGCACTCACTG
AGGAAGCCAAAGCGTTTTATATCCACCATGGTTTCAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCCGGCTTCCT
CAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT135899 WP_003857131.1 NZ_CP042566:c2275447-2275181 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT135899 NZ_CP042566:c2275447-2275181 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGCACGGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGGCGTGTATTCAATT
TTAACGATGAACAGTACGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References