Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 55642..56264 Replicon plasmid pE47_002
Accession NZ_CP042558
Organism Acinetobacter baumannii strain E47

Toxin (Protein)


Gene name vapC Uniprot ID R9BAE0
Locus tag FR761_RS20540 Protein ID WP_000639719.1
Coordinates 55869..56264 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID R9B9I8
Locus tag FR761_RS20535 Protein ID WP_000401521.1
Coordinates 55642..55872 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FR761_RS20515 50952..52007 + 1056 WP_000991568.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
FR761_RS20520 52204..52594 + 391 Protein_50 DNA polymerase V -
FR761_RS20525 52682..53364 + 683 Protein_51 IS3-like element ISAcsp5 family transposase -
FR761_RS20530 53728..55061 + 1334 Protein_52 ISNCY family transposase -
FR761_RS20535 55642..55872 + 231 WP_000401521.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
FR761_RS20540 55869..56264 + 396 WP_000639719.1 type II toxin-antitoxin system VapC family toxin Toxin
FR761_RS20545 56425..56856 + 432 WP_001011655.1 hypothetical protein -
FR761_RS20550 57034..57165 + 132 Protein_56 IS5/IS1182 family transposase -
FR761_RS20565 58508..58636 + 129 Protein_58 transposase -
FR761_RS20570 59113..59334 - 222 WP_031978535.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..59744 59744
- inside IScluster/Tn - - 52661..58457 5796


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(7-37)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14897.19 Da        Isoelectric Point: 6.4640

>T135895 WP_000639719.1 NZ_CP042558:55869-56264 [Acinetobacter baumannii]
MIYLLDTNICIYVINNKPQQVFERFKQYQLGQLAISSITASELAFGVEKSGSERNKQALNKFLSPLEILPYDEQAIWHYA
KLRQNLQSTGKPIGSLDMLIAAHALALDVVLVTNNTKEFERIDGLKLENWV

Download         Length: 396 bp

>T135895 NZ_CP042558:55869-56264 [Acinetobacter baumannii]
ATGATTTACCTCTTAGACACAAATATTTGTATCTATGTCATCAACAATAAGCCTCAACAAGTTTTTGAGCGCTTTAAGCA
ATATCAACTCGGCCAGCTTGCGATTTCGAGTATCACGGCATCTGAGCTGGCTTTTGGTGTAGAGAAGTCTGGATCTGAAC
GCAATAAACAGGCGTTAAACAAGTTTTTGTCACCTTTAGAGATTCTTCCTTACGATGAACAGGCGATTTGGCATTACGCC
AAATTACGCCAGAATCTTCAATCTACAGGTAAACCGATTGGCAGCTTAGATATGCTGATCGCTGCTCATGCTTTGGCATT
GGATGTTGTATTAGTTACGAACAATACAAAAGAATTTGAACGAATTGATGGTCTGAAGCTAGAGAATTGGGTCTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8759.04 Da        Isoelectric Point: 4.7708

>AT135895 WP_000401521.1 NZ_CP042558:55642-55872 [Acinetobacter baumannii]
MEIAKVFQTGRSQAVRLPKAFRFNGTEVAIKSFGRGVLLMPIDNPWDVMLEAINEFEVGFQLERADQGEQLREEFR

Download         Length: 231 bp

>AT135895 NZ_CP042558:55642-55872 [Acinetobacter baumannii]
ATGGAAATTGCGAAAGTATTTCAAACTGGTCGCAGTCAGGCTGTTCGCTTGCCTAAAGCCTTTCGCTTTAATGGCACGGA
AGTGGCCATCAAAAGCTTCGGTCGTGGTGTATTACTCATGCCCATCGACAATCCTTGGGATGTCATGTTAGAAGCAATAA
ATGAGTTTGAGGTTGGATTCCAATTGGAGCGAGCTGATCAAGGCGAACAGCTCCGTGAGGAGTTCAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N6V6E5

Antitoxin

Source ID Structure
AlphaFold DB A0A2N6V6E6

References