Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2825..3413 Replicon plasmid pE47_001
Accession NZ_CP042557
Organism Acinetobacter baumannii strain E47

Toxin (Protein)


Gene name relE Uniprot ID N9CKJ9
Locus tag FR761_RS18580 Protein ID WP_004647749.1
Coordinates 2825..3121 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag FR761_RS18585 Protein ID WP_004969304.1
Coordinates 3123..3413 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FR761_RS18570 521..1087 + 567 WP_043041640.1 recombinase family protein -
FR761_RS18575 1308..2381 + 1074 WP_043041639.1 hypothetical protein -
FR761_RS18580 2825..3121 + 297 WP_004647749.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FR761_RS18585 3123..3413 + 291 WP_004969304.1 putative addiction module antidote protein Antitoxin
FR761_RS18595 3514..4839 - 1326 WP_008942541.1 ISNCY family transposase -
FR761_RS18605 5016..6470 - 1455 WP_026438532.1 SulP family inorganic anion transporter -
FR761_RS18610 6720..6929 - 210 WP_004976362.1 hypothetical protein -
FR761_RS18615 7196..7564 - 369 Protein_8 IS1-like element ISAba3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaOXA-96 / msr(E) / mph(E) / aac(3)-IId / cmlB1 / sul1 / qacE / catB3 / blaIMP-4 / dfrA19 / blaCARB-2 / aph(3')-Ia - 1..327867 327867
- inside IScluster/Tn blaOXA-96 / msr(E) / mph(E) - 3514..22101 18587


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-92)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11584.25 Da        Isoelectric Point: 5.8801

>T135892 WP_004647749.1 NZ_CP042557:2825-3121 [Acinetobacter baumannii]
MIEIKRLPEFDEWLDGIKDNMTRIRLNRRLDKVQRGNWGDIKPLQDGVWEMREFFGSGWRMYYIQHGDVVIVMLGGGDKS
TQQQDIDRAVKLSKTLED

Download         Length: 297 bp

>T135892 NZ_CP042557:2825-3121 [Acinetobacter baumannii]
ATGATTGAAATTAAACGTCTTCCAGAATTTGATGAATGGTTGGATGGCATTAAAGACAATATGACCCGTATCCGCCTGAA
TCGTCGATTAGATAAGGTTCAACGTGGAAACTGGGGAGACATTAAACCTCTCCAAGATGGCGTTTGGGAAATGAGAGAAT
TCTTCGGTTCTGGATGGAGGATGTATTACATCCAACATGGTGACGTTGTGATTGTAATGCTTGGTGGTGGAGATAAATCA
ACTCAACAACAAGACATCGATCGGGCAGTCAAACTATCGAAAACATTGGAGGATTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10524.19 Da        Isoelectric Point: 5.1133

>AT135892 WP_004969304.1 NZ_CP042557:3123-3413 [Acinetobacter baumannii]
MVKVADLPSFDMAESLKTEEDIVMYLNMVLEENDPAELAHALGVIAKARGMTQIAKEAGIGREALYKALRQDSAPRFDTI
NRVVNALGLKLTVQHA

Download         Length: 291 bp

>AT135892 NZ_CP042557:3123-3413 [Acinetobacter baumannii]
ATGGTTAAAGTCGCTGATTTACCAAGTTTTGATATGGCTGAGTCGCTCAAAACTGAAGAAGACATTGTGATGTATCTCAA
TATGGTTCTTGAAGAAAATGATCCAGCTGAATTAGCCCATGCACTTGGTGTTATTGCTAAAGCTCGTGGCATGACTCAAA
TCGCTAAAGAAGCAGGGATTGGGCGTGAAGCACTCTACAAAGCCCTACGTCAGGATTCAGCACCACGTTTTGATACGATT
AATCGTGTAGTAAATGCTTTAGGCTTAAAGCTCACAGTACAACACGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References