Detailed information of TA system TA135891

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 3512931..3513572
• Replicon: chromosome
• Accession: NZ_CP042556
• Organism: Acinetobacter baumannii strain E47

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A829RKD8
• Locus tag: FR761_RS17070
• Protein ID: WP_002125600.1
• Coordinates: 3512931..3513320 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: FR761_RS17075
• Protein ID: WP_011860336.1
• Coordinates: 3513327..3513572 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FR761_RS17055	3508049..3510244	-	2196	WP_001158905.1	TRAP transporter large permease subunit	-
FR761_RS17060	3510432..3510998	-	567	WP_000651536.1	rhombosortase	-
FR761_RS17065	3511076..3512161	-	1086	WP_000049106.1	hypothetical protein	-
FR761_RS17070	3512931..3513320	-	390	WP_002125600.1	hypothetical protein	Toxin
FR761_RS17075	3513327..3513572	-	246	WP_011860336.1	succinate dehydrogenase assembly factor 2	Antitoxin
FR761_RS17080	3513772..3514134	+	363	Protein_3284	acyl-CoA dehydrogenase family protein	-
FR761_RS17090	3515444..3516256	+	813	Protein_3286	acyl-CoA dehydrogenase family protein	-
FR761_RS17095	3516305..3517795	-	1491	WP_002125480.1	NAD(P)/FAD-dependent oxidoreductase	-
FR761_RS17100	3517881..3518384	-	504	WP_106631126.1	IS630 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (6-78)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15662.98 Da
• Isoelectric Point: 10.4623

>T135891 WP_002125600.1 NZ_CP042556:c3513320-3512931 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKIWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKKLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T135891 NZ_CP042556:c3513320-3512931 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAAATATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCACGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAAAACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9842.27 Da
• Isoelectric Point: 4.9001

>AT135891 WP_011860336.1 NZ_CP042556:c3513572-3513327 [Acinetobacter baumannii]
MTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLKHYVH
G

Nucleotide

• Length: 246 bp

>AT135891 NZ_CP042556:c3513572-3513327 [Acinetobacter baumannii]
ATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTTTGACCCTTATGT
GAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCATTGTTTGCTGAGTTGGTAGAACAGGAAGACCCTGATTTAC
TAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAACACTATGTTCAT
GGTTAA

Structures

Toxin

• AlphaFold DB: A0A829RKD8