Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 2109116..2109595 Replicon chromosome
Accession NZ_CP042556
Organism Acinetobacter baumannii strain E47

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag FR761_RS10140 Protein ID WP_079283165.1
Coordinates 2109398..2109595 (-) Length 66 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag FR761_RS10135 Protein ID WP_000985610.1
Coordinates 2109116..2109397 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FR761_RS10120 2105324..2106535 + 1212 WP_086231556.1 alpha/beta hydrolase -
FR761_RS10125 2106628..2107716 - 1089 Protein_1943 LLM class flavin-dependent oxidoreductase -
FR761_RS10130 2107956..2108888 - 933 WP_002056344.1 IS5-like element ISAba13 family transposase -
FR761_RS10135 2109116..2109397 - 282 WP_000985610.1 putative addiction module antidote protein Antitoxin
FR761_RS10140 2109398..2109595 - 198 WP_079283165.1 addiction module killer protein Toxin
FR761_RS10145 2109601..2110820 - 1220 Protein_1947 IS3 family transposase -
FR761_RS10150 2110930..2111154 + 225 Protein_1948 IS1 family transposase -
FR761_RS10160 2111588..2111863 + 276 WP_001133624.1 metal/formaldehyde-sensitive transcriptional repressor -
FR761_RS10165 2111885..2112997 + 1113 WP_038343718.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
FR761_RS10170 2113228..2114058 + 831 WP_004740248.1 S-formylglutathione hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2092854..2133850 40996
- inside IScluster/Tn - - 2107956..2110820 2864


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(6-60)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-91)


Sequences

Toxin        


Download         Length: 66 a.a.        Molecular weight: 7391.56 Da        Isoelectric Point: 9.5998

>T135889 WP_079283165.1 NZ_CP042556:c2109595-2109398 [Acinetobacter baumannii]
IKKSPTNPVRFSVSELRFFFGPGYRIYYCKQGQRVVILLAGGDKSTQSKDIKLALQLAQDLEEEL

Download         Length: 198 bp

>T135889 NZ_CP042556:c2109595-2109398 [Acinetobacter baumannii]
ATAAAAAAGTCTCCGACAAACCCGGTACGTTTCAGTGTTTCTGAGTTACGTTTCTTCTTTGGACCTGGCTATAGGATTTA
TTACTGCAAGCAAGGGCAAAGGGTCGTTATTCTCTTAGCAGGCGGAGATAAGTCTACGCAAAGTAAAGATATAAAACTTG
CCCTACAATTAGCACAAGATTTAGAGGAGGAGCTGTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10109.67 Da        Isoelectric Point: 8.0018

>AT135889 WP_000985610.1 NZ_CP042556:c2109397-2109116 [Acinetobacter baumannii]
MAIKLRKWDSAEHLKTEEDMQAYLQACIDESNGDAAFIAKALGNIAKAKGMAQLSRDTGLGRESLYKALSGDVNPSFDTV
IKVVKALNLRLAI

Download         Length: 282 bp

>AT135889 NZ_CP042556:c2109397-2109116 [Acinetobacter baumannii]
ATGGCTATCAAACTTCGTAAATGGGATAGTGCTGAGCATCTTAAAACAGAAGAAGATATGCAAGCTTACCTACAAGCCTG
TATCGATGAATCTAATGGTGATGCTGCATTCATTGCTAAAGCTTTAGGTAACATTGCTAAAGCTAAAGGAATGGCTCAAT
TATCACGAGATACAGGTCTAGGCCGAGAAAGTCTTTACAAAGCACTTTCTGGTGATGTTAACCCTAGTTTTGATACTGTG
ATTAAAGTTGTAAAAGCACTGAATTTACGCTTAGCAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References