135885

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 199735..200261 Replicon plasmid pC45_001
Accession NZ_CP042552
Organism Enterobacter hormaechei strain C45

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag FR772_RS25800 Protein ID WP_000323025.1
Coordinates 199735..200022 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag FR772_RS25805 Protein ID WP_000534858.1
Coordinates 200022..200261 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FR772_RS27620 195305..195481 - 177 WP_001371930.1 hypothetical protein -
FR772_RS25770 195992..196936 + 945 WP_000778029.1 DUF5417 domain-containing protein -
FR772_RS25775 197032..197634 + 603 WP_012695474.1 hypothetical protein -
FR772_RS25780 197694..198044 + 351 WP_151608595.1 hypothetical protein -
FR772_RS25785 198091..198294 + 204 WP_001015183.1 hypothetical protein -
FR772_RS25790 198576..198896 + 321 WP_000332796.1 hypothetical protein -
FR772_RS25795 199505..199663 - 159 WP_001447866.1 type I toxin-antitoxin system Hok family toxin -
FR772_RS25800 199735..200022 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
FR772_RS25805 200022..200261 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
FR772_RS25815 200524..201447 - 924 WP_000167917.1 cation diffusion facilitator family transporter -
FR772_RS25820 201647..202219 - 573 WP_001515348.1 cytochrome b/b6 domain-containing protein -
FR772_RS25825 202695..203933 - 1239 WP_000219087.1 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaTEM-1B / catA2 / tet(D) / mcr-9 / aph(6)-Id / aph(3'')-Ib / dfrA19 / sul1 / qnrA1 / qacE / ere(A) / aac(6')-IIc / blaSHV-12 - 1..288659 288659


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T135885 WP_000323025.1 NZ_CP042552:c200022-199735 [Enterobacter hormaechei]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T135885 NZ_CP042552:c200022-199735 [Enterobacter hormaechei]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT135885 WP_000534858.1 NZ_CP042552:c200261-200022 [Enterobacter hormaechei]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT135885 NZ_CP042552:c200261-200022 [Enterobacter hormaechei]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References