Detailed information of TA system TA135882

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4144402..4145059
• Replicon: chromosome
• Accession: NZ_CP042551
• Organism: Enterobacter hormaechei strain C45

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A179PSF7
• Locus tag: FR772_RS20255
• Protein ID: WP_017382887.1
• Coordinates: 4144402..4144812 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: FR772_RS20260
• Protein ID: WP_151608570.1
• Coordinates: 4144793..4145059 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FR772_RS20235	4140400..4142133	-	1734	WP_032649421.1	single-stranded-DNA-specific exonuclease RecJ	-
FR772_RS20240	4142139..4142852	-	714	WP_015571792.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
FR772_RS20245	4142881..4143777	-	897	WP_003863442.1	site-specific tyrosine recombinase XerD	-
FR772_RS20250	4143879..4144400	+	522	WP_032649423.1	flavodoxin FldB	-
FR772_RS20255	4144402..4144812	-	411	WP_017382887.1	protein YgfX	Toxin
FR772_RS20260	4144793..4145059	-	267	WP_151608570.1	FAD assembly factor SdhE	Antitoxin
FR772_RS20265	4145354..4146334	+	981	WP_022649306.1	tRNA-modifying protein YgfZ	-
FR772_RS20270	4146446..4147105	-	660	WP_003863433.1	hemolysin III family protein	-
FR772_RS20275	4147372..4148103	+	732	WP_032649427.1	MurR/RpiR family transcriptional regulator	-
FR772_RS20280	4148220..4149653	+	1434	WP_017382891.1	6-phospho-beta-glucosidase BglA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16321.21 Da
• Isoelectric Point: 11.4775

>T135882 WP_017382887.1 NZ_CP042551:c4144812-4144402 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Nucleotide

• Length: 411 bp

>T135882 NZ_CP042551:c4144812-4144402 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCCTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGGCTGGTGGCGGC
ACTGGTGTTATTGGTGCCGTGGCCGCTTAGCTATACCCCTCTGTGGTTGCTATTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGGACGCCGTGGATGCTTAATACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10555.02 Da
• Isoelectric Point: 5.1340

>AT135882 WP_151608570.1 NZ_CP042551:c4145059-4144793 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIRTRN
QERGPVAI

Nucleotide

• Length: 267 bp

>AT135882 NZ_CP055179:c4703486-4703196 [Shigella flexneri]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Structures

Toxin

• AlphaFold DB: A0A179PSF7