135872

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2487578..2488317 Replicon chromosome
Accession NZ_CP042551
Organism Enterobacter hormaechei strain C45

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag FR772_RS12125 Protein ID WP_003857133.1
Coordinates 2487578..2488063 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag FR772_RS12130 Protein ID WP_003857131.1
Coordinates 2488051..2488317 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FR772_RS12100 2482591..2483559 - 969 WP_022652343.1 IS5-like element IS903B family transposase -
FR772_RS12105 2483634..2484266 + 633 WP_001567369.1 hypothetical protein -
FR772_RS12110 2484295..2485698 - 1404 WP_001567368.1 ISNCY-like element ISKpn21 family transposase -
FR772_RS12115 2485977..2486942 + 966 WP_032648329.1 hypothetical protein -
FR772_RS12120 2486958..2487527 + 570 WP_032648331.1 hypothetical protein -
FR772_RS12125 2487578..2488063 - 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
FR772_RS12130 2488051..2488317 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
FR772_RS12135 2488381..2489310 - 930 WP_032648334.1 LysR family transcriptional regulator -
FR772_RS12140 2489440..2490822 + 1383 WP_032648336.1 MFS transporter -
FR772_RS12145 2490844..2491839 - 996 WP_017382342.1 DUF2891 domain-containing protein -
FR772_RS12150 2491849..2492835 - 987 WP_017382341.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T135872 WP_003857133.1 NZ_CP042551:c2488063-2487578 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T135872 NZ_CP042551:c2488063-2487578 [Enterobacter hormaechei]
GTGGGACGTGTAACAGCACCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGCGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGCAAGCGACAGGTAATCTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATACTTGCCCGTCTGGCTGTGGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGTGTAGCAGAGAATATCGGGGTGCGGGCGATTATGGTTCATGCACTCACTG
AGGAAGCCAAAGCGTTTTATATCCACCATGGTTTCAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCCGGCTTCCC
CAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT135872 WP_003857131.1 NZ_CP042551:c2488317-2488051 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT135872 NZ_CP055179:c2699168-2699102 [Shigella flexneri]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References