Detailed information of TA system TA135870

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 1756476..1757389
• Replicon: chromosome
• Accession: NZ_CP042551
• Organism: Enterobacter hormaechei strain C45

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: FR772_RS08480
• Protein ID: WP_032647883.1
• Coordinates: 1756476..1756949 (-)
• Length: 158 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: FR772_RS08485
• Protein ID: WP_023296216.1
• Coordinates: 1756946..1757389 (-)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FR772_RS08460	1752635..1753945	+	1311	WP_032647879.1	type I-F CRISPR-associated protein Csy1	-
FR772_RS08465	1753942..1754877	+	936	WP_032647880.1	type I-F CRISPR-associated protein Csy2	-
FR772_RS08470	1754891..1755889	+	999	WP_032647881.1	type I-F CRISPR-associated protein Csy3	-
FR772_RS08475	1755899..1756453	+	555	WP_032647882.1	type I-F CRISPR-associated endoribonuclease Cas6/Csy4	-
FR772_RS08480	1756476..1756949	-	474	WP_032647883.1	RES domain-containing protein	Toxin
FR772_RS08485	1756946..1757389	-	444	WP_023296216.1	DUF2384 domain-containing protein	Antitoxin
FR772_RS08490	1758487..1758705	-	219	WP_002211347.1	translation initiation factor IF-1	-
FR772_RS08495	1758990..1759694	-	705	WP_032668747.1	leucyl/phenylalanyl-tRNA--protein transferase	-
FR772_RS08500	1759740..1761461	-	1722	WP_032647885.1	cysteine/glutathione ABC transporter ATP-binding protein/permease CydC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-147)

Antitoxin

• Antitoxin Xre (15-147)

Sequences

Toxin

Protein

• Length: 158 a.a.
• Molecular weight: 17569.96 Da
• Isoelectric Point: 5.5555

>T135870 WP_032647883.1 NZ_CP042551:c1756949-1756476 [Enterobacter hormaechei]
MIFYRLVTGRFASEAWSGSGANQYGGRWNHKGHPAVYVSTSISLASLEILVHVRKDTVLNQYQLFSINIPDDQIDYLDKA
WLPEDWQENPAPVSTMDLGTGWLQANSALALILPSCIIPYENNAILNPLHPAFRKALNSVELLPFNFDTRLAEKTAP

Nucleotide

• Length: 474 bp

>T135870 NZ_CP042551:c1756949-1756476 [Enterobacter hormaechei]
ATGATTTTTTATCGTCTGGTGACAGGACGTTTTGCCAGCGAAGCGTGGAGTGGCAGTGGTGCAAACCAGTATGGCGGACG
CTGGAATCATAAAGGCCATCCTGCCGTGTATGTCTCCACCTCCATCTCGCTGGCTTCACTGGAAATTCTGGTGCATGTCA
GAAAAGACACCGTGCTGAACCAGTACCAGCTTTTCAGCATTAATATCCCGGATGATCAGATTGATTACCTGGATAAAGCG
TGGCTGCCCGAGGACTGGCAGGAAAATCCGGCGCCGGTATCAACGATGGATCTGGGTACCGGTTGGTTGCAGGCTAACAG
CGCTCTCGCACTCATCTTACCCTCCTGCATCATTCCCTATGAAAACAACGCCATACTTAATCCATTGCATCCGGCATTCC
GCAAAGCACTTAATTCTGTTGAGTTACTGCCTTTTAATTTTGATACCCGTCTCGCAGAAAAAACCGCACCCTGA

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16512.81 Da
• Isoelectric Point: 6.4819

>AT135870 WP_023296216.1 NZ_CP042551:c1757389-1756946 [Enterobacter hormaechei]
MRTWVPAQRPADNTLWRYAGLPASRGMRLIEYLNQGLPVSVLDNIHEWTDMSKAEILRVTGINERNVARRKSTGRTLTPD
ESERVARFVRVLDAAVDYFGSKEEAWNWLQLPVRGLGNVAPVDLIATETGALEVTDLIGRLEHGVFA

Nucleotide

• Length: 444 bp

>AT135870 NZ_CP042551:c1757389-1756946 [Enterobacter hormaechei]
ATGAGAACATGGGTTCCTGCGCAAAGGCCGGCTGATAACACGCTGTGGCGCTACGCCGGTTTACCTGCAAGCAGAGGCAT
GCGGCTGATTGAATATCTCAATCAAGGATTACCCGTCAGCGTCCTCGACAATATTCACGAGTGGACGGACATGTCGAAAG
CGGAGATTTTACGCGTCACGGGAATTAACGAGCGTAACGTTGCCCGCCGCAAAAGTACGGGCCGGACGCTGACGCCCGAC
GAGAGCGAACGTGTGGCGCGTTTCGTTCGGGTACTGGATGCGGCCGTCGATTATTTCGGCAGTAAAGAAGAGGCATGGAA
CTGGTTGCAGTTACCGGTACGTGGGCTTGGCAATGTTGCGCCTGTCGATCTGATTGCCACGGAAACCGGTGCGCTGGAAG
TTACCGATTTGATTGGTCGGCTGGAGCACGGAGTGTTCGCATGA