Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1221656..1222276 Replicon chromosome
Accession NZ_CP042551
Organism Enterobacter hormaechei strain C45

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag FR772_RS05830 Protein ID WP_015571250.1
Coordinates 1221656..1221874 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag FR772_RS05835 Protein ID WP_006809850.1
Coordinates 1221902..1222276 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FR772_RS05800 1217668..1217928 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
FR772_RS05805 1217931..1218071 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
FR772_RS05810 1218068..1218778 - 711 WP_032647453.1 GNAT family N-acetyltransferase -
FR772_RS05815 1218880..1220340 + 1461 WP_032647455.1 PLP-dependent aminotransferase family protein -
FR772_RS05820 1220312..1220779 - 468 WP_015571252.1 extracytoplasmic function sigma factor YlaC -
FR772_RS05825 1220896..1221447 - 552 WP_032647457.1 maltose O-acetyltransferase -
FR772_RS05830 1221656..1221874 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
FR772_RS05835 1221902..1222276 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
FR772_RS05840 1222787..1225933 - 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit -
FR772_RS05845 1225956..1227149 - 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T135869 WP_015571250.1 NZ_CP042551:c1221874-1221656 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T135869 NZ_CP055179:1822013-1822264 [Shigella flexneri]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT135869 WP_006809850.1 NZ_CP042551:c1222276-1221902 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT135869 NZ_CP042551:c1222276-1221902 [Enterobacter hormaechei]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGAAGAAAGTAACCATGGCTGGGTGAACGATCCAACGTCTGCTATCAATTTACAGCTCAACGAGCTGATCGAGC
ATATCGCCACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGTCT
ATTTCGCTGCTTCACTAATGTCAGCAGAGCTAATCCGGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References