Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 727208..727784 Replicon chromosome
Accession NZ_CP042551
Organism Enterobacter hormaechei strain C45

Toxin (Protein)


Gene name shpA Uniprot ID A0A800YKM1
Locus tag FR772_RS03485 Protein ID WP_015572580.1
Coordinates 727208..727495 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A801DSF4
Locus tag FR772_RS03490 Protein ID WP_017694570.1
Coordinates 727482..727784 (+) Length 101 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FR772_RS03460 722326..723021 + 696 WP_032647138.1 winged helix-turn-helix domain-containing protein -
FR772_RS03465 723171..723641 + 471 WP_032647140.1 MarR family transcriptional regulator -
FR772_RS03470 723638..724705 + 1068 WP_026094404.1 HlyD family secretion protein -
FR772_RS03475 724695..725771 + 1077 WP_015572578.1 DUF2955 domain-containing protein -
FR772_RS03480 725768..727039 - 1272 WP_032647142.1 DUF445 domain-containing protein -
FR772_RS03485 727208..727495 + 288 WP_015572580.1 BrnT family toxin Toxin
FR772_RS03490 727482..727784 + 303 WP_017694570.1 BrnA antitoxin family protein Antitoxin
FR772_RS03495 727813..728451 - 639 WP_032647144.1 LysE family translocator -
FR772_RS03500 728490..729242 - 753 WP_015572582.1 AraC family transcriptional regulator -
FR772_RS03505 729396..730766 + 1371 WP_032647147.1 NAD-dependent succinate-semialdehyde dehydrogenase -
FR772_RS03510 730944..731489 - 546 WP_006810254.1 porin -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11296.81 Da        Isoelectric Point: 7.3587

>T135867 WP_015572580.1 NZ_CP042551:727208-727495 [Enterobacter hormaechei]
MPIEYEWDSNKAKSNLQKHAIRFEDAVLVFDDPCHLSVQDRYENGEFRWQTIGLVQGVIVILVAHTVRFESGDEIIRIIS
ARKADRKERRRYEHR

Download         Length: 288 bp

>T135867 NZ_CP042551:727208-727495 [Enterobacter hormaechei]
ATGCCTATAGAGTATGAATGGGATAGCAATAAGGCGAAAAGCAATCTGCAAAAACACGCCATTCGTTTTGAAGATGCAGT
TCTGGTTTTTGACGATCCCTGCCATTTGTCTGTTCAGGATCGTTATGAAAACGGGGAGTTTCGCTGGCAAACCATTGGTC
TTGTACAGGGTGTTATTGTCATTCTGGTCGCGCACACGGTACGTTTTGAAAGCGGGGATGAAATCATACGTATCATCAGT
GCGCGTAAAGCGGATCGTAAAGAGAGGAGGCGTTATGAGCATCGTTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11482.13 Da        Isoelectric Point: 10.4094

>AT135867 WP_017694570.1 NZ_CP042551:727482-727784 [Enterobacter hormaechei]
MSIVKHKRGSAPEVSARREAELKALADKPDREIDYSDIPATEDDRWAGAVRGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp

>AT135867 NZ_CP042551:727482-727784 [Enterobacter hormaechei]
ATGAGCATCGTTAAACATAAACGCGGTAGTGCACCGGAAGTGAGTGCCCGCCGGGAGGCTGAACTCAAAGCGCTGGCGGA
TAAACCCGACAGGGAAATTGATTACAGCGATATACCGGCCACGGAGGATGATCGCTGGGCCGGTGCCGTGCGGGGAAAAT
TCTATCGACCGCTCAAAACTCAGGCATCAGTACGCATTGACGCCGACGTGATGGAGTGGCTTAAACGGCCAGGGAAAGGT
TACCAGACGCGGCTTAATGCCATTTTGCGCGAGGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References