Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 5559729..5560517 Replicon chromosome
Accession NZ_CP042545
Organism Klebsiella michiganensis strain C52

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag FR848_RS26415 Protein ID WP_038424005.1
Coordinates 5559729..5560106 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag FR848_RS26420 Protein ID WP_038424004.1
Coordinates 5560158..5560517 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FR848_RS26385 5555588..5556595 - 1008 WP_038424009.1 restriction endonuclease -
FR848_RS26390 5556666..5557499 - 834 WP_038424008.1 DUF4942 domain-containing protein -
FR848_RS26400 5557971..5558948 + 978 WP_051800673.1 glycosyltransferase -
FR848_RS26405 5559008..5559211 - 204 WP_038424007.1 DUF957 domain-containing protein -
FR848_RS26410 5559241..5559732 - 492 WP_038424006.1 hypothetical protein -
FR848_RS26415 5559729..5560106 - 378 WP_038424005.1 TA system toxin CbtA family protein Toxin
FR848_RS26420 5560158..5560517 - 360 WP_038424004.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
FR848_RS26425 5560540..5560761 - 222 WP_038424003.1 DUF987 domain-containing protein -
FR848_RS26430 5560776..5561255 - 480 WP_038424002.1 DNA repair protein RadC -
FR848_RS26435 5561267..5561752 - 486 WP_038424001.1 antirestriction protein -
FR848_RS26440 5561832..5562653 - 822 WP_038424000.1 DUF945 domain-containing protein -
FR848_RS26445 5562764..5562976 - 213 WP_010434180.1 hypothetical protein -
FR848_RS26450 5563057..5563416 - 360 WP_038423999.1 hypothetical protein -
FR848_RS26455 5563471..5563935 - 465 WP_038423998.1 hypothetical protein -
FR848_RS26460 5563989..5564666 - 678 WP_038423997.1 WYL domain-containing protein -
FR848_RS26465 5564726..5565454 - 729 WP_038423996.1 DUF3944 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 5554015..5579513 25498


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(2-112)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14204.11 Da        Isoelectric Point: 5.7237

>T135862 WP_038424005.1 NZ_CP042545:c5560106-5559729 [Klebsiella michiganensis]
MQTQQLSSTEETSPRPSPVEIWQQLLSYLLDRHYGLTLNDTPFGNDGVIQEHIEAGISLCDAVNFIVEKYALVRIERRGF
NAETQSPLLSSIDILRARKATGLMTRNGYRMVTDITTGKYREMQP

Download         Length: 378 bp

>T135862 NZ_CP042545:c5560106-5559729 [Klebsiella michiganensis]
ATGCAAACTCAACAACTATCCTCAACGGAGGAGACCTCACCACGTCCGTCACCGGTGGAGATCTGGCAACAGCTTCTGAG
CTACCTGCTGGATCGTCACTACGGCCTGACGCTCAACGACACGCCTTTCGGCAATGATGGTGTGATCCAGGAACATATCG
AAGCCGGTATCTCACTGTGCGACGCCGTGAATTTTATCGTGGAAAAGTACGCCCTGGTGCGCATCGAACGTCGCGGTTTT
AACGCAGAAACTCAGTCGCCGCTTCTCTCCAGTATCGATATTCTCCGCGCCCGCAAAGCCACCGGGCTGATGACGCGCAA
CGGCTACAGAATGGTAACCGATATCACCACCGGCAAATACCGCGAGATGCAGCCATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13224.98 Da        Isoelectric Point: 5.0063

>AT135862 WP_038424004.1 NZ_CP042545:c5560517-5560158 [Klebsiella michiganensis]
MQNTTNVANHDIAEPWWGLKPTVTPCFGTRLVQEGNRLHYLADRASITGTFSDADLRHLDQTFPQLLKQLELMLVSGELN
PRYQDCVTLYTKGLTCEADSLGSCGYVYIALYPTPATTA

Download         Length: 360 bp

>AT135862 NZ_CP042545:c5560517-5560158 [Klebsiella michiganensis]
ATGCAGAACACAACAAACGTAGCAAATCATGATATTGCCGAACCCTGGTGGGGACTTAAACCCACCGTCACGCCGTGTTT
TGGCACACGCCTGGTGCAGGAAGGCAACCGCCTGCATTACCTGGCTGACCGCGCCAGTATCACCGGCACCTTTAGTGACG
CGGATTTACGCCATCTCGACCAGACATTTCCGCAACTGCTCAAACAGCTTGAACTGATGCTGGTTTCCGGTGAACTCAAT
CCCCGCTATCAGGACTGTGTCACTCTCTACACAAAAGGGCTGACCTGCGAGGCCGACAGCCTGGGTAGTTGCGGCTATGT
CTATATTGCGCTTTACCCAACACCTGCAACAACCGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References