Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 86653..87179 Replicon plasmid pC4_001
Accession NZ_CP042541
Organism Enterobacter hormaechei strain C4

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag FR758_RS23175 Protein ID WP_000323025.1
Coordinates 86892..87179 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID J5W3H0
Locus tag FR758_RS23170 Protein ID WP_004196370.1
Coordinates 86653..86892 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FR758_RS23145 81921..83297 + 1377 WP_004196363.1 chromate efflux transporter -
FR758_RS23150 83328..84017 - 690 WP_013087175.1 hypothetical protein -
FR758_RS23155 84031..84768 - 738 WP_008460272.1 HupE/UreJ family protein -
FR758_RS23160 84812..85177 - 366 WP_009651956.1 hypothetical protein -
FR758_RS23170 86653..86892 + 240 WP_004196370.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
FR758_RS23175 86892..87179 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
FR758_RS23180 87246..88280 - 1035 Protein_95 IS481 family transposase -
FR758_RS23185 88352..88510 + 159 WP_013087178.1 type I toxin-antitoxin system Hok family toxin -
FR758_RS23190 89386..89700 + 315 WP_044157807.1 hypothetical protein -
FR758_RS23195 89761..90222 + 462 WP_013087181.1 hypothetical protein -
FR758_RS23200 90310..90510 + 201 WP_013087182.1 hypothetical protein -
FR758_RS23205 90551..91342 + 792 WP_013087183.1 N-6 DNA methylase -
FR758_RS23210 91384..91719 + 336 WP_013087184.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid dfrA14 / catA2 / blaTEM-1B / aph(6)-Id / aph(3'')-Ib / sul2 - 1..155361 155361
- inside IScluster/Tn - - 85213..88280 3067


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T135846 WP_000323025.1 NZ_CP042541:86892-87179 [Enterobacter hormaechei]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T135846 NZ_CP042541:86892-87179 [Enterobacter hormaechei]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9018.43 Da        Isoelectric Point: 4.3894

>AT135846 WP_004196370.1 NZ_CP042541:86653-86892 [Enterobacter hormaechei]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL

Download         Length: 240 bp

>AT135846 NZ_CP042541:86653-86892 [Enterobacter hormaechei]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTTGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4QRH4

References