Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3825419..3826076 Replicon chromosome
Accession NZ_CP042540
Organism Enterobacter hormaechei strain C4

Toxin (Protein)


Gene name cptA Uniprot ID A0A7T9SH06
Locus tag FR758_RS18270 Protein ID WP_023295382.1
Coordinates 3825419..3825829 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag FR758_RS18275 Protein ID WP_003863437.1
Coordinates 3825810..3826076 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FR758_RS18250 3821417..3823150 - 1734 WP_017382886.1 single-stranded-DNA-specific exonuclease RecJ -
FR758_RS18255 3823156..3823869 - 714 WP_045334239.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FR758_RS18260 3823898..3824794 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
FR758_RS18265 3824896..3825417 + 522 WP_015571793.1 flavodoxin FldB -
FR758_RS18270 3825419..3825829 - 411 WP_023295382.1 protein YgfX Toxin
FR758_RS18275 3825810..3826076 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
FR758_RS18280 3826371..3827351 + 981 WP_039269839.1 tRNA-modifying protein YgfZ -
FR758_RS18285 3827463..3828122 - 660 WP_003863433.1 hemolysin III family protein -
FR758_RS18290 3828389..3829117 + 729 WP_151548504.1 MurR/RpiR family transcriptional regulator -
FR758_RS18295 3829237..3830670 + 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16291.18 Da        Isoelectric Point: 11.4775

>T135842 WP_023295382.1 NZ_CP042540:c3825829-3825419 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGAPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T135842 NZ_CP042540:c3825829-3825419 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCCTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTGGCGGC
ACTGGTGTTATTGGTGCCGTGGCCGCTTAGCTATACCCCTCTGTGGTTGCTATTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGCGCGCCGTGGATGCTTAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT135842 WP_003863437.1 NZ_CP042540:c3826076-3825810 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT135842 NZ_CP042540:c3826076-3825810 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T9SH06

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References