Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 2653359..2654438 Replicon chromosome
Accession NZ_CP042540
Organism Enterobacter hormaechei strain C4

Toxin (Protein)


Gene name panT Uniprot ID A0A7G3F048
Locus tag FR758_RS12730 Protein ID WP_039270560.1
Coordinates 2653359..2653946 (-) Length 196 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A7G3ETZ9
Locus tag FR758_RS12735 Protein ID WP_039270559.1
Coordinates 2653968..2654438 (-) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FR758_RS12705 2649268..2650731 + 1464 WP_017693253.1 16S rRNA (cytosine(1407)-C(5))-methyltransferase RsmF -
FR758_RS12710 2650839..2651078 + 240 WP_003859885.1 YebV family protein -
FR758_RS12715 2651113..2651757 - 645 WP_015570293.1 protein-serine/threonine phosphatase -
FR758_RS12720 2651925..2652905 + 981 WP_039270562.1 VirK/YbjX family protein -
FR758_RS12725 2652951..2653130 + 180 WP_039270561.1 hypothetical protein -
FR758_RS12730 2653359..2653946 - 588 WP_039270560.1 hypothetical protein Toxin
FR758_RS12735 2653968..2654438 - 471 WP_039270559.1 SocA family protein Antitoxin
FR758_RS12740 2654760..2655077 - 318 WP_039270558.1 hypothetical protein -
FR758_RS12745 2655345..2655605 - 261 WP_039270557.1 hypothetical protein -
FR758_RS12750 2655589..2655873 - 285 WP_039270555.1 phage holin family protein -
FR758_RS12755 2656013..2656210 - 198 WP_127850788.1 hypothetical protein -
FR758_RS12760 2656240..2656674 - 435 WP_039270553.1 hypothetical protein -
FR758_RS12770 2658686..2659201 - 516 WP_039270551.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2636364..2666416 30052


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(27-122)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21051.73 Da        Isoelectric Point: 4.9672

>T135832 WP_039270560.1 NZ_CP042540:c2653946-2653359 [Enterobacter hormaechei]
VSIVEDIFKVIGAASGLEQIRTDSDPTKTSQSKNSNPKTESSKGSGSAEEKGKSETSDGAAPSEPDDKAEREAEEFGSNT
GALHEFMQQNRMDSLQAQLDMLKSGVRDKIADANGKEIDNVLRKKMASFTFSFMVCWCLFVGTMFVSYLIAHEGKPPPET
MIALLGTSTLSIVGLVGFVVSGLFKSRKEGSEKEK

Download         Length: 588 bp

>T135832 NZ_CP042540:c2653946-2653359 [Enterobacter hormaechei]
GTGTCAATCGTGGAAGACATTTTTAAAGTCATCGGTGCGGCATCTGGGCTTGAGCAGATCCGCACCGATTCTGATCCTAC
CAAGACATCCCAATCCAAAAATAGCAATCCCAAAACAGAATCTTCAAAAGGAAGCGGTTCAGCTGAAGAAAAGGGTAAAT
CCGAAACTTCTGACGGAGCTGCACCAAGCGAACCTGACGACAAAGCAGAACGTGAAGCGGAAGAGTTTGGCTCTAATACT
GGCGCGTTGCATGAATTCATGCAGCAAAATCGTATGGATAGCTTGCAAGCACAACTGGATATGTTGAAATCAGGTGTGCG
AGATAAGATTGCTGATGCGAATGGTAAAGAAATTGACAACGTTCTTCGTAAGAAGATGGCATCCTTCACATTTTCATTTA
TGGTTTGCTGGTGCCTATTCGTTGGTACTATGTTTGTTTCTTATCTTATCGCACATGAAGGGAAGCCTCCTCCTGAAACC
ATGATTGCTTTACTTGGCACCAGTACACTTTCGATTGTTGGACTTGTTGGCTTTGTAGTTAGTGGCCTGTTTAAGTCGCG
CAAAGAAGGTAGTGAAAAAGAGAAATAA

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17314.82 Da        Isoelectric Point: 8.0154

>AT135832 WP_039270559.1 NZ_CP042540:c2654438-2653968 [Enterobacter hormaechei]
MYSPVQVANRFVMLGNQHMNPLTHMQLQKLTYIAHGYYLALTGRPLINEPVSAWKYGPVIPGMYDAFKDFGNRPVTNPVM
SPYGMGVFDPQAESVIGAVFQYYGNKGGIELSTLTHLPGTPWSRAYNGFSSTIIPDGVIKSYYDDLVANRQTCQGL

Download         Length: 471 bp

>AT135832 NZ_CP042540:c2654438-2653968 [Enterobacter hormaechei]
ATGTACAGTCCGGTACAGGTAGCCAATCGATTTGTTATGTTGGGCAATCAACATATGAATCCTCTGACTCATATGCAACT
TCAAAAGTTGACATACATTGCCCATGGTTATTATCTGGCTTTAACAGGGCGTCCGTTAATCAATGAACCTGTTTCTGCTT
GGAAGTATGGCCCTGTAATTCCAGGAATGTATGACGCATTTAAAGACTTTGGAAACAGGCCAGTTACAAACCCTGTCATG
AGTCCTTACGGAATGGGAGTATTCGACCCGCAAGCGGAAAGTGTCATTGGTGCAGTATTCCAATATTACGGCAACAAGGG
CGGGATTGAATTGTCCACTTTAACCCATTTACCTGGCACTCCATGGTCCAGAGCATACAACGGGTTTAGTTCTACGATTA
TACCTGACGGTGTAATCAAGTCTTACTACGATGATCTTGTTGCCAATCGGCAAACTTGTCAAGGCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G3F048

Antitoxin

Source ID Structure
AlphaFold DB A0A7G3ETZ9

References