Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1084660..1085280 Replicon chromosome
Accession NZ_CP042540
Organism Enterobacter hormaechei strain C4

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag FR758_RS05195 Protein ID WP_015571250.1
Coordinates 1084660..1084878 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag FR758_RS05200 Protein ID WP_006809850.1
Coordinates 1084906..1085280 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FR758_RS05165 1080672..1080932 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
FR758_RS05170 1080935..1081075 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
FR758_RS05175 1081072..1081782 - 711 WP_032670463.1 GNAT family N-acetyltransferase -
FR758_RS05180 1081884..1083344 + 1461 WP_039271537.1 PLP-dependent aminotransferase family protein -
FR758_RS05185 1083316..1083783 - 468 WP_023296041.1 hypothetical protein -
FR758_RS05190 1083900..1084451 - 552 WP_015571251.1 maltose O-acetyltransferase -
FR758_RS05195 1084660..1084878 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
FR758_RS05200 1084906..1085280 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
FR758_RS05205 1085791..1088937 - 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit -
FR758_RS05210 1088960..1090153 - 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T135830 WP_015571250.1 NZ_CP042540:c1084878-1084660 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T135830 NZ_CP042540:c1084878-1084660 [Enterobacter hormaechei]
ATGTCTGATAAACCATTAACAAAAGTCGATTATTTGATGCGCCTGCGACGCTGCCAGTCAATTGACACCCTTGAACGAGT
TATTGAGAAAAATAAATACGAGCTGTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTTGCTGAGC
TGACCATGAATAAACTGTATGACAAGATCCCCTCTTCGGTGTGGAAATTTGTTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT135830 WP_006809850.1 NZ_CP042540:c1085280-1084906 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT135830 NZ_CP042540:c1085280-1084906 [Enterobacter hormaechei]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGAAGAAAGTAACCATGGCTGGGTGAACGATCCAACGTCTGCTATCAATTTACAGCTCAACGAGCTGATCGAGC
ATATCGCCACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGTCT
ATTTCGCTGCTTCACTAATGTCAGCAGAGCTAATCCGGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References