Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 4451640..4453360 Replicon chromosome
Accession NZ_CP042530
Organism Klebsiella aerogenes strain C9

Toxin (Protein)


Gene name pmenT Uniprot ID -
Locus tag FR830_RS21655 Protein ID WP_151585550.1
Coordinates 4452704..4453360 (-) Length 219 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID -
Locus tag FR830_RS21650 Protein ID WP_151585547.1
Coordinates 4451640..4452707 (-) Length 356 a.a.

Genomic Context

FR830_RS21630FR830_RS21640FR830_RS21645FR830_RS21650FR830_RS21655FR830_RS21660FR830_RS21665FR830_RS21670
Location: 4447139..4447390 (252 bp)
Type: Others
Protein ID: WP_151585537.1
Location: 4447808..4448524 (717 bp)
Type: Others
Protein ID: WP_151585540.1
Location: 4448524..4451619 (3096 bp)
Type: Others
Protein ID: WP_151585544.1
Location: 4451640..4452707 (1068 bp)
Type: Antitoxin
Protein ID: WP_151585547.1
Location: 4452704..4453360 (657 bp)
Type: Toxin
Protein ID: WP_151585550.1
Location: 4453373..4454686 (1314 bp)
Type: Others
Protein ID: WP_151585553.1
Location: 4454686..4457124 (2439 bp)
Type: Others
Protein ID: WP_151585556.1
Location: 4457164..4457403 (240 bp)
Type: Others
Protein ID: WP_012543063.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FR830_RS216304447139..4447390+252WP_151585537.1hypothetical protein-
FR830_RS216404447808..4448524-717WP_151585540.1M48 family metallopeptidase-
FR830_RS216454448524..4451619-3096WP_151585544.1HsdR family type I site-specific deoxyribonuclease-
FR830_RS216504451640..4452707-1068WP_151585547.1macro domain-containing proteinAntitoxin
FR830_RS216554452704..4453360-657WP_151585550.1DUF4433 domain-containing proteinToxin
FR830_RS216604453373..4454686-1314WP_151585553.1restriction endonuclease subunit S-
FR830_RS216654454686..4457124-2439WP_151585556.1type I restriction-modification system subunit M-
FR830_RS216704457164..4457403-240WP_012543063.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--4422661..445897736316


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(17-217)

Antitoxin

Macro domain

(18-129)


Sequences

Toxin        


Download         Length: 219 a.a.        Molecular weight: 25330.73 Da        Isoelectric Point: 6.4009

>T135826 WP_151585550.1 NZ_CP042530:c4453360-4452704 [Klebsiella aerogenes]
MAYDYSANLNPEKALIWRIVHRDNIPWILDNGLHCGNSQVQAENWVNIGNPELIDKRAGHPVPAGTGGTLHDYVPFYFTP
FSPMLMNIHSGRGGIMQRPNEEIVILVSSLRHVAAQNVPFVFTDSHAYYNWTNYYTRLDDLNQIDWPMLQARDFRRDPDD
PAKFERYQAEALIWKHCPITLLSGMVCYDNDVRLQLEQWLLQRNLTMPVHARAGWYFS

Download         Length: 657 bp

>T135826 NZ_CP055170:c1844990-1844883 [Shigella flexneri]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 356 a.a.        Molecular weight: 40968.20 Da        Isoelectric Point: 6.0616

>AT135826 WP_151585547.1 NZ_CP042530:c4452707-4451640 [Klebsiella aerogenes]
MMKYTQGNLLDAPVEALVNTVNTVGVMGKGIALMFKERFPDNMKSYALACKQKQVMTGKMFITETSELMGPRWIVNFPTK
QHWRADSRMEWIEEGLQDLRRFLIEEKVQSIAIPPLGAGNGGLNWPDVRARIESALGDLQDTEILIYEPTEKYQNVAKNT
GVKKLTPARAMIAELVRRYWVQGMECSLLEIQKLAWLLQRAIELHQQEDVLKLRFEAHNYGPFSPNLNHLLNALDGTYLK
AEKRIPDSQPLDVIWFNDREKEHVNLWLNNEAKEWLPALEQVSQLIDGFESPFGLELLATVDWLLTRGECQPTLDSVKEG
LHQWPAGERWASRKMKLFDDHHLQFAINRVMEFHC

Download         Length: 1068 bp

>AT135826 NZ_CP042530:c4452707-4451640 [Klebsiella aerogenes]
ATGATGAAATATACACAAGGCAATTTACTGGATGCGCCCGTGGAAGCTCTGGTGAATACGGTTAATACCGTCGGTGTCAT
GGGTAAAGGCATCGCGCTGATGTTCAAAGAGCGCTTCCCCGACAATATGAAATCCTATGCCCTCGCCTGCAAACAAAAGC
AGGTCATGACCGGCAAGATGTTTATTACCGAAACCAGCGAACTAATGGGGCCGCGCTGGATCGTCAACTTCCCTACCAAG
CAGCACTGGCGCGCCGACTCCCGCATGGAGTGGATCGAAGAAGGTTTGCAGGATCTGCGCCGCTTTTTGATCGAAGAGAA
AGTGCAATCCATCGCTATTCCCCCGCTGGGCGCGGGCAACGGCGGCCTGAACTGGCCAGACGTGCGGGCGCGGATTGAAT
CTGCGCTAGGTGACCTTCAGGACACGGAAATTCTGATTTATGAGCCTACCGAAAAATACCAGAACGTCGCCAAGAACACC
GGCGTAAAAAAGCTTACTCCCGCCAGAGCGATGATCGCTGAACTGGTGCGCCGCTACTGGGTGCAGGGCATGGAGTGCAG
CCTGCTGGAAATCCAGAAGCTGGCATGGCTGTTACAACGTGCTATTGAACTGCACCAGCAGGAGGACGTTTTAAAGCTGC
GCTTTGAGGCGCACAATTACGGTCCCTTTTCCCCCAACCTGAACCATCTGCTTAATGCGCTGGACGGTACCTATCTGAAA
GCCGAGAAACGCATCCCAGACAGCCAGCCGCTGGACGTGATCTGGTTTAACGATCGGGAAAAAGAACACGTCAACCTCTG
GCTGAATAACGAGGCCAAAGAGTGGCTACCGGCGCTTGAGCAGGTCAGTCAGTTGATTGACGGCTTTGAATCACCGTTTG
GTCTGGAGCTGCTGGCGACCGTTGACTGGCTGCTGACCCGAGGAGAATGCCAGCCCACTCTGGATTCAGTAAAAGAGGGG
CTACACCAGTGGCCTGCCGGTGAACGCTGGGCCAGCCGTAAGATGAAGCTGTTTGATGATCATCATCTTCAATTCGCCAT
AAACCGTGTGATGGAGTTCCATTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
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Antitoxin

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Source
ID
Structure
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References