Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 4451640..4453360 Replicon chromosome
Accession NZ_CP042530
Organism Klebsiella aerogenes strain C9

Toxin (Protein)


Gene name pmenT Uniprot ID -
Locus tag FR830_RS21655 Protein ID WP_151585550.1
Coordinates 4452704..4453360 (-) Length 219 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID -
Locus tag FR830_RS21650 Protein ID WP_151585547.1
Coordinates 4451640..4452707 (-) Length 356 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FR830_RS21630 4447139..4447390 + 252 WP_151585537.1 hypothetical protein -
FR830_RS21640 4447808..4448524 - 717 WP_151585540.1 M48 family metallopeptidase -
FR830_RS21645 4448524..4451619 - 3096 WP_151585544.1 HsdR family type I site-specific deoxyribonuclease -
FR830_RS21650 4451640..4452707 - 1068 WP_151585547.1 macro domain-containing protein Antitoxin
FR830_RS21655 4452704..4453360 - 657 WP_151585550.1 DUF4433 domain-containing protein Toxin
FR830_RS21660 4453373..4454686 - 1314 WP_151585553.1 restriction endonuclease subunit S -
FR830_RS21665 4454686..4457124 - 2439 WP_151585556.1 type I restriction-modification system subunit M -
FR830_RS21670 4457164..4457403 - 240 WP_012543063.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4422661..4458977 36316


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(17-217)

Antitoxin

Macro domain

(18-129)


Sequences

Toxin        


Download         Length: 219 a.a.        Molecular weight: 25330.73 Da        Isoelectric Point: 6.4009

>T135826 WP_151585550.1 NZ_CP042530:c4453360-4452704 [Klebsiella aerogenes]
MAYDYSANLNPEKALIWRIVHRDNIPWILDNGLHCGNSQVQAENWVNIGNPELIDKRAGHPVPAGTGGTLHDYVPFYFTP
FSPMLMNIHSGRGGIMQRPNEEIVILVSSLRHVAAQNVPFVFTDSHAYYNWTNYYTRLDDLNQIDWPMLQARDFRRDPDD
PAKFERYQAEALIWKHCPITLLSGMVCYDNDVRLQLEQWLLQRNLTMPVHARAGWYFS

Download         Length: 657 bp

>T135826 NZ_CP055170:c1844990-1844883 [Shigella flexneri]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 356 a.a.        Molecular weight: 40968.20 Da        Isoelectric Point: 6.0616

>AT135826 WP_151585547.1 NZ_CP042530:c4452707-4451640 [Klebsiella aerogenes]
MMKYTQGNLLDAPVEALVNTVNTVGVMGKGIALMFKERFPDNMKSYALACKQKQVMTGKMFITETSELMGPRWIVNFPTK
QHWRADSRMEWIEEGLQDLRRFLIEEKVQSIAIPPLGAGNGGLNWPDVRARIESALGDLQDTEILIYEPTEKYQNVAKNT
GVKKLTPARAMIAELVRRYWVQGMECSLLEIQKLAWLLQRAIELHQQEDVLKLRFEAHNYGPFSPNLNHLLNALDGTYLK
AEKRIPDSQPLDVIWFNDREKEHVNLWLNNEAKEWLPALEQVSQLIDGFESPFGLELLATVDWLLTRGECQPTLDSVKEG
LHQWPAGERWASRKMKLFDDHHLQFAINRVMEFHC

Download         Length: 1068 bp

>AT135826 NZ_CP042530:c4452707-4451640 [Klebsiella aerogenes]
ATGATGAAATATACACAAGGCAATTTACTGGATGCGCCCGTGGAAGCTCTGGTGAATACGGTTAATACCGTCGGTGTCAT
GGGTAAAGGCATCGCGCTGATGTTCAAAGAGCGCTTCCCCGACAATATGAAATCCTATGCCCTCGCCTGCAAACAAAAGC
AGGTCATGACCGGCAAGATGTTTATTACCGAAACCAGCGAACTAATGGGGCCGCGCTGGATCGTCAACTTCCCTACCAAG
CAGCACTGGCGCGCCGACTCCCGCATGGAGTGGATCGAAGAAGGTTTGCAGGATCTGCGCCGCTTTTTGATCGAAGAGAA
AGTGCAATCCATCGCTATTCCCCCGCTGGGCGCGGGCAACGGCGGCCTGAACTGGCCAGACGTGCGGGCGCGGATTGAAT
CTGCGCTAGGTGACCTTCAGGACACGGAAATTCTGATTTATGAGCCTACCGAAAAATACCAGAACGTCGCCAAGAACACC
GGCGTAAAAAAGCTTACTCCCGCCAGAGCGATGATCGCTGAACTGGTGCGCCGCTACTGGGTGCAGGGCATGGAGTGCAG
CCTGCTGGAAATCCAGAAGCTGGCATGGCTGTTACAACGTGCTATTGAACTGCACCAGCAGGAGGACGTTTTAAAGCTGC
GCTTTGAGGCGCACAATTACGGTCCCTTTTCCCCCAACCTGAACCATCTGCTTAATGCGCTGGACGGTACCTATCTGAAA
GCCGAGAAACGCATCCCAGACAGCCAGCCGCTGGACGTGATCTGGTTTAACGATCGGGAAAAAGAACACGTCAACCTCTG
GCTGAATAACGAGGCCAAAGAGTGGCTACCGGCGCTTGAGCAGGTCAGTCAGTTGATTGACGGCTTTGAATCACCGTTTG
GTCTGGAGCTGCTGGCGACCGTTGACTGGCTGCTGACCCGAGGAGAATGCCAGCCCACTCTGGATTCAGTAAAAGAGGGG
CTACACCAGTGGCCTGCCGGTGAACGCTGGGCCAGCCGTAAGATGAAGCTGTTTGATGATCATCATCTTCAATTCGCCAT
AAACCGTGTGATGGAGTTCCATTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References