Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | pmenTA/darT(toxin) |
Location | 4451640..4453360 | Replicon | chromosome |
Accession | NZ_CP042530 | ||
Organism | Klebsiella aerogenes strain C9 |
Toxin (Protein)
Gene name | pmenT | Uniprot ID | - |
Locus tag | FR830_RS21655 | Protein ID | WP_151585550.1 |
Coordinates | 4452704..4453360 (-) | Length | 219 a.a. |
Antitoxin (Protein)
Gene name | pmenA | Uniprot ID | - |
Locus tag | FR830_RS21650 | Protein ID | WP_151585547.1 |
Coordinates | 4451640..4452707 (-) | Length | 356 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FR830_RS21630 | 4447139..4447390 | + | 252 | WP_151585537.1 | hypothetical protein | - |
FR830_RS21640 | 4447808..4448524 | - | 717 | WP_151585540.1 | M48 family metallopeptidase | - |
FR830_RS21645 | 4448524..4451619 | - | 3096 | WP_151585544.1 | HsdR family type I site-specific deoxyribonuclease | - |
FR830_RS21650 | 4451640..4452707 | - | 1068 | WP_151585547.1 | macro domain-containing protein | Antitoxin |
FR830_RS21655 | 4452704..4453360 | - | 657 | WP_151585550.1 | DUF4433 domain-containing protein | Toxin |
FR830_RS21660 | 4453373..4454686 | - | 1314 | WP_151585553.1 | restriction endonuclease subunit S | - |
FR830_RS21665 | 4454686..4457124 | - | 2439 | WP_151585556.1 | type I restriction-modification system subunit M | - |
FR830_RS21670 | 4457164..4457403 | - | 240 | WP_012543063.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 4422661..4458977 | 36316 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 219 a.a. Molecular weight: 25330.73 Da Isoelectric Point: 6.4009
>T135826 WP_151585550.1 NZ_CP042530:c4453360-4452704 [Klebsiella aerogenes]
MAYDYSANLNPEKALIWRIVHRDNIPWILDNGLHCGNSQVQAENWVNIGNPELIDKRAGHPVPAGTGGTLHDYVPFYFTP
FSPMLMNIHSGRGGIMQRPNEEIVILVSSLRHVAAQNVPFVFTDSHAYYNWTNYYTRLDDLNQIDWPMLQARDFRRDPDD
PAKFERYQAEALIWKHCPITLLSGMVCYDNDVRLQLEQWLLQRNLTMPVHARAGWYFS
MAYDYSANLNPEKALIWRIVHRDNIPWILDNGLHCGNSQVQAENWVNIGNPELIDKRAGHPVPAGTGGTLHDYVPFYFTP
FSPMLMNIHSGRGGIMQRPNEEIVILVSSLRHVAAQNVPFVFTDSHAYYNWTNYYTRLDDLNQIDWPMLQARDFRRDPDD
PAKFERYQAEALIWKHCPITLLSGMVCYDNDVRLQLEQWLLQRNLTMPVHARAGWYFS
Download Length: 657 bp
>T135826 NZ_CP055170:c1844990-1844883 [Shigella flexneri]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 356 a.a. Molecular weight: 40968.20 Da Isoelectric Point: 6.0616
>AT135826 WP_151585547.1 NZ_CP042530:c4452707-4451640 [Klebsiella aerogenes]
MMKYTQGNLLDAPVEALVNTVNTVGVMGKGIALMFKERFPDNMKSYALACKQKQVMTGKMFITETSELMGPRWIVNFPTK
QHWRADSRMEWIEEGLQDLRRFLIEEKVQSIAIPPLGAGNGGLNWPDVRARIESALGDLQDTEILIYEPTEKYQNVAKNT
GVKKLTPARAMIAELVRRYWVQGMECSLLEIQKLAWLLQRAIELHQQEDVLKLRFEAHNYGPFSPNLNHLLNALDGTYLK
AEKRIPDSQPLDVIWFNDREKEHVNLWLNNEAKEWLPALEQVSQLIDGFESPFGLELLATVDWLLTRGECQPTLDSVKEG
LHQWPAGERWASRKMKLFDDHHLQFAINRVMEFHC
MMKYTQGNLLDAPVEALVNTVNTVGVMGKGIALMFKERFPDNMKSYALACKQKQVMTGKMFITETSELMGPRWIVNFPTK
QHWRADSRMEWIEEGLQDLRRFLIEEKVQSIAIPPLGAGNGGLNWPDVRARIESALGDLQDTEILIYEPTEKYQNVAKNT
GVKKLTPARAMIAELVRRYWVQGMECSLLEIQKLAWLLQRAIELHQQEDVLKLRFEAHNYGPFSPNLNHLLNALDGTYLK
AEKRIPDSQPLDVIWFNDREKEHVNLWLNNEAKEWLPALEQVSQLIDGFESPFGLELLATVDWLLTRGECQPTLDSVKEG
LHQWPAGERWASRKMKLFDDHHLQFAINRVMEFHC
Download Length: 1068 bp
>AT135826 NZ_CP042530:c4452707-4451640 [Klebsiella aerogenes]
ATGATGAAATATACACAAGGCAATTTACTGGATGCGCCCGTGGAAGCTCTGGTGAATACGGTTAATACCGTCGGTGTCAT
GGGTAAAGGCATCGCGCTGATGTTCAAAGAGCGCTTCCCCGACAATATGAAATCCTATGCCCTCGCCTGCAAACAAAAGC
AGGTCATGACCGGCAAGATGTTTATTACCGAAACCAGCGAACTAATGGGGCCGCGCTGGATCGTCAACTTCCCTACCAAG
CAGCACTGGCGCGCCGACTCCCGCATGGAGTGGATCGAAGAAGGTTTGCAGGATCTGCGCCGCTTTTTGATCGAAGAGAA
AGTGCAATCCATCGCTATTCCCCCGCTGGGCGCGGGCAACGGCGGCCTGAACTGGCCAGACGTGCGGGCGCGGATTGAAT
CTGCGCTAGGTGACCTTCAGGACACGGAAATTCTGATTTATGAGCCTACCGAAAAATACCAGAACGTCGCCAAGAACACC
GGCGTAAAAAAGCTTACTCCCGCCAGAGCGATGATCGCTGAACTGGTGCGCCGCTACTGGGTGCAGGGCATGGAGTGCAG
CCTGCTGGAAATCCAGAAGCTGGCATGGCTGTTACAACGTGCTATTGAACTGCACCAGCAGGAGGACGTTTTAAAGCTGC
GCTTTGAGGCGCACAATTACGGTCCCTTTTCCCCCAACCTGAACCATCTGCTTAATGCGCTGGACGGTACCTATCTGAAA
GCCGAGAAACGCATCCCAGACAGCCAGCCGCTGGACGTGATCTGGTTTAACGATCGGGAAAAAGAACACGTCAACCTCTG
GCTGAATAACGAGGCCAAAGAGTGGCTACCGGCGCTTGAGCAGGTCAGTCAGTTGATTGACGGCTTTGAATCACCGTTTG
GTCTGGAGCTGCTGGCGACCGTTGACTGGCTGCTGACCCGAGGAGAATGCCAGCCCACTCTGGATTCAGTAAAAGAGGGG
CTACACCAGTGGCCTGCCGGTGAACGCTGGGCCAGCCGTAAGATGAAGCTGTTTGATGATCATCATCTTCAATTCGCCAT
AAACCGTGTGATGGAGTTCCATTGCTGA
ATGATGAAATATACACAAGGCAATTTACTGGATGCGCCCGTGGAAGCTCTGGTGAATACGGTTAATACCGTCGGTGTCAT
GGGTAAAGGCATCGCGCTGATGTTCAAAGAGCGCTTCCCCGACAATATGAAATCCTATGCCCTCGCCTGCAAACAAAAGC
AGGTCATGACCGGCAAGATGTTTATTACCGAAACCAGCGAACTAATGGGGCCGCGCTGGATCGTCAACTTCCCTACCAAG
CAGCACTGGCGCGCCGACTCCCGCATGGAGTGGATCGAAGAAGGTTTGCAGGATCTGCGCCGCTTTTTGATCGAAGAGAA
AGTGCAATCCATCGCTATTCCCCCGCTGGGCGCGGGCAACGGCGGCCTGAACTGGCCAGACGTGCGGGCGCGGATTGAAT
CTGCGCTAGGTGACCTTCAGGACACGGAAATTCTGATTTATGAGCCTACCGAAAAATACCAGAACGTCGCCAAGAACACC
GGCGTAAAAAAGCTTACTCCCGCCAGAGCGATGATCGCTGAACTGGTGCGCCGCTACTGGGTGCAGGGCATGGAGTGCAG
CCTGCTGGAAATCCAGAAGCTGGCATGGCTGTTACAACGTGCTATTGAACTGCACCAGCAGGAGGACGTTTTAAAGCTGC
GCTTTGAGGCGCACAATTACGGTCCCTTTTCCCCCAACCTGAACCATCTGCTTAATGCGCTGGACGGTACCTATCTGAAA
GCCGAGAAACGCATCCCAGACAGCCAGCCGCTGGACGTGATCTGGTTTAACGATCGGGAAAAAGAACACGTCAACCTCTG
GCTGAATAACGAGGCCAAAGAGTGGCTACCGGCGCTTGAGCAGGTCAGTCAGTTGATTGACGGCTTTGAATCACCGTTTG
GTCTGGAGCTGCTGGCGACCGTTGACTGGCTGCTGACCCGAGGAGAATGCCAGCCCACTCTGGATTCAGTAAAAGAGGGG
CTACACCAGTGGCCTGCCGGTGAACGCTGGGCCAGCCGTAAGATGAAGCTGTTTGATGATCATCATCTTCAATTCGCCAT
AAACCGTGTGATGGAGTTCCATTGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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