Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2517822..2518561 Replicon chromosome
Accession NZ_CP042530
Organism Klebsiella aerogenes strain C9

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag FR830_RS12245 Protein ID WP_047048975.1
Coordinates 2518076..2518561 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A0H3FSM9
Locus tag FR830_RS12240 Protein ID WP_015705366.1
Coordinates 2517822..2518088 (+) Length 89 a.a.

Genomic Context

FR830_RS12220FR830_RS12225FR830_RS12230FR830_RS12240FR830_RS12245FR830_RS12250FR830_RS12255FR830_RS12265FR830_RS12235FR830_RS12260
Location: 2514114..2514731 (618 bp)
Type: Others
Protein ID: WP_045360840.1
Location: 2514827..2515324 (498 bp)
Type: Others
Protein ID: WP_045360838.1
Location: 2515729..2516259 (531 bp)
Type: Others
Protein ID: WP_058676118.1
Location: 2517822..2518088 (267 bp)
Type: Antitoxin
Protein ID: WP_015705366.1
Location: 2518076..2518561 (486 bp)
Type: Toxin
Protein ID: WP_047048975.1
Location: 2518633..2520249 (1617 bp)
Type: Others
Protein ID: WP_047048973.1
Location: 2520368..2521468 (1101 bp)
Type: Others
Protein ID: WP_015366663.1
Location: 2521944..2523014 (1071 bp)
Type: Others
Protein ID: WP_015705361.1
Location: 2516314..2517549 (1236 bp)
Type: Others
Protein ID: WP_020078885.1
Location: 2521525..2521683 (159 bp)
Type: Others
Protein ID: WP_002903230.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FR830_RS122202514114..2514731+618WP_045360840.1response regulator transcription factor-
FR830_RS122252514827..2515324+498WP_045360838.1heme-binding protein-
FR830_RS122302515729..2516259+531WP_058676118.1N-acetyltransferase-
FR830_RS122352516314..2517549-1236WP_020078885.1MFS transporter-
FR830_RS122402517822..2518088+267WP_015705366.1DUF1778 domain-containing proteinAntitoxin
FR830_RS122452518076..2518561+486WP_047048975.1GNAT family N-acetyltransferaseToxin
FR830_RS122502518633..2520249+1617WP_047048973.1FAD-NAD(P)-binding protein-
FR830_RS122552520368..2521468+1101WP_015366663.1NADH:flavin oxidoreductase/NADH oxidase-
FR830_RS122602521525..2521683-159WP_002903230.1YqaE/Pmp3 family membrane protein-
FR830_RS122652521944..2523014+1071WP_015705361.1mannonate dehydratase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17587.26 Da        Isoelectric Point: 8.8793

>T135824 WP_047048975.1 NZ_CP042530:2518076-2518561 [Klebsiella aerogenes]
MGKISAPAPLSSHHQIAEFCCGETVLDQWLKQRGLKNQAQGAARTFVVCKEESHQVVGFYSLATGSVNHTEATGGLRRNM
PDPIPVIILARLAIDCAFHGQGLGADLLHDALLRSYRVAENVGVRALMVHALTDSAKRFYLHHGFKASTTQERTLFLALP
K

Download         Length: 486 bp

>T135824 NZ_CP042530:2518076-2518561 [Klebsiella aerogenes]
ATGGGAAAAATAAGCGCGCCTGCACCGCTATCTTCACACCATCAGATCGCGGAATTTTGTTGTGGAGAAACGGTTCTCGA
TCAATGGCTGAAACAGCGAGGATTGAAAAACCAGGCTCAGGGCGCCGCGAGAACTTTTGTGGTCTGCAAGGAAGAGAGCC
ATCAGGTGGTGGGGTTTTATTCGTTAGCAACCGGCAGCGTTAATCACACGGAAGCCACTGGCGGCCTGCGGCGCAATATG
CCCGATCCTATCCCGGTCATCATTCTCGCCCGCCTGGCGATCGACTGCGCGTTTCACGGACAGGGGCTGGGAGCTGATTT
ACTCCATGATGCGCTGTTACGCAGTTATCGCGTTGCCGAAAATGTTGGCGTACGTGCCCTGATGGTCCATGCCCTGACCG
ATAGCGCGAAACGATTCTATTTACACCACGGATTCAAAGCCTCAACCACCCAGGAACGCACTCTTTTCCTCGCGTTGCCT
AAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10085.56 Da        Isoelectric Point: 4.6558

>AT135824 WP_015705366.1 NZ_CP042530:2517822-2518088 [Klebsiella aerogenes]
MKSDIQLNIRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNLSDEQYAEFIDMLDAPVEANPALDKLL
ARKPQWEK

Download         Length: 267 bp

>AT135824 NZ_CP055170:c834468-834208 [Shigella flexneri]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0H3FSM9

References