Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 842374..843031 Replicon chromosome
Accession NZ_CP042530
Organism Klebsiella aerogenes strain C9

Toxin (Protein)


Gene name cptA Uniprot ID A0A0H3FM52
Locus tag FR830_RS04135 Protein ID WP_015369792.1
Coordinates 842621..843031 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0H3FJK6
Locus tag FR830_RS04130 Protein ID WP_015369791.1
Coordinates 842374..842640 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FR830_RS04105 837601..839034 - 1434 WP_047053696.1 6-phospho-beta-glucosidase BglA -
FR830_RS04110 839148..839882 - 735 WP_015703423.1 MurR/RpiR family transcriptional regulator -
FR830_RS04115 839933..840244 + 312 WP_015703422.1 N(4)-acetylcytidine aminohydrolase -
FR830_RS04120 840409..841068 + 660 WP_008806429.1 hemolysin III family protein -
FR830_RS04125 841167..842150 - 984 WP_015369790.1 tRNA-modifying protein YgfZ -
FR830_RS04130 842374..842640 + 267 WP_015369791.1 FAD assembly factor SdhE Antitoxin
FR830_RS04135 842621..843031 + 411 WP_015369792.1 protein YgfX Toxin
FR830_RS04140 843039..843560 - 522 WP_151584328.1 flavodoxin FldB -
FR830_RS04145 843661..844557 + 897 WP_015703420.1 site-specific tyrosine recombinase XerD -
FR830_RS04150 844580..845293 + 714 WP_151584331.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FR830_RS04155 845299..847032 + 1734 WP_151584334.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15887.69 Da        Isoelectric Point: 10.0200

>T135814 WP_015369792.1 NZ_CP042530:842621-843031 [Klebsiella aerogenes]
VVLWQSDLRISWRSQWFSLLLHGVVAAIVLLMPWPLSYTPIWLLLLSLVVFDCVRSQRRIHACQGEIKLLIDSRLRWQKT
EWDIVGTPWVISSGMLLRLKHAETGRSQHLWVAADSMDAGEWRDLRRLVLQKPAHD

Download         Length: 411 bp

>T135814 NZ_CP042530:842621-843031 [Klebsiella aerogenes]
GTGGTCCTGTGGCAATCTGATTTACGTATTTCCTGGCGTTCGCAGTGGTTCTCGCTGCTGCTGCACGGGGTGGTGGCGGC
GATAGTGCTGCTCATGCCCTGGCCGTTAAGCTACACCCCGATTTGGCTCCTGTTGCTATCGCTGGTGGTGTTTGACTGCG
TGCGCAGCCAGCGGCGGATCCACGCCTGCCAGGGAGAAATTAAGCTGTTGATCGATTCCCGTTTACGGTGGCAAAAAACG
GAATGGGATATCGTCGGGACGCCATGGGTTATCAGCAGCGGGATGCTGCTGCGCCTGAAGCATGCGGAAACCGGCCGTAG
CCAGCATTTGTGGGTGGCGGCGGATAGCATGGATGCGGGGGAATGGCGGGATTTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCACGACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10579.09 Da        Isoelectric Point: 5.6963

>AT135814 WP_015369791.1 NZ_CP042530:842374-842640 [Klebsiella aerogenes]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGKPADAQLQRMINLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT135814 NZ_CP042530:842374-842640 [Klebsiella aerogenes]
ATGGACATTAACAACAAAGCTCGCATCCACTGGGCATGCCGCCGCGGTATGCGCGAACTCGATATCTCCATCATGCCGTT
TTTCGAGTATGAGTACGACACGCTCAGCGATGACGACAAGCGCCTGTTCATCCGTTTGCTGGAGAACGATGATCCGGATC
TGTTTAACTGGCTGATGAATCACGGCAAGCCGGCAGATGCGCAACTTCAACGGATGATTAATTTAATCCAGACTCGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FM52

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FJK6

References